Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063777990> ?p ?o ?g. }
- W2063777990 endingPage "475" @default.
- W2063777990 startingPage "465" @default.
- W2063777990 abstract "Interleukin-6 (IL-6) is the major growth factor for the malignant plasma cell clone in patients with multiple myeloma (MM). Although interferon-alpha (IFN-alpha) has been widely used as maintenance therapy in MM, controversy exists as to its clinical utility. This review summarizes data showing that cell growth arrest brought about by type I (IFNs-alpha/beta) and type II (IFN-gamma) IFNs occurs in part through utilization/modification of various components of the otherwise stimulatory Jak-STAT and Ras signaling pathways triggered by IL-6. Recent experimental results indicating that IFN-alpha acts as a survival factor for certain myeloma cell lines and frequently induces endogenous IL-6 expression may help to explain the conflicting clinical findings obtained in this heterogeneous disease with this usually potent growth inhibitor. By comparison, consistent antiproliferative activity exhibited by IFN-gamma on IL-6-dependent myeloma cell lines and primary myeloma cells from patients suggests that further investigation of the possible value of this cytokine in the treatment of MM may be warranted." @default.
- W2063777990 created "2016-06-24" @default.
- W2063777990 creator A5007800819 @default.
- W2063777990 creator A5031658033 @default.
- W2063777990 date "1998-01-01" @default.
- W2063777990 modified "2023-09-26" @default.
- W2063777990 title "Growth Control Mechanisms in Multiple Myeloma" @default.
- W2063777990 cites W131140191 @default.
- W2063777990 cites W134083461 @default.
- W2063777990 cites W135486017 @default.
- W2063777990 cites W1479767677 @default.
- W2063777990 cites W1479791469 @default.
- W2063777990 cites W1496384357 @default.
- W2063777990 cites W1505669067 @default.
- W2063777990 cites W1510533289 @default.
- W2063777990 cites W1521367633 @default.
- W2063777990 cites W1539584528 @default.
- W2063777990 cites W1542742520 @default.
- W2063777990 cites W1543116608 @default.
- W2063777990 cites W1565618380 @default.
- W2063777990 cites W1585517331 @default.
- W2063777990 cites W1602943807 @default.
- W2063777990 cites W164934141 @default.
- W2063777990 cites W1720235364 @default.
- W2063777990 cites W1743711678 @default.
- W2063777990 cites W1747682552 @default.
- W2063777990 cites W1766651653 @default.
- W2063777990 cites W1917885463 @default.
- W2063777990 cites W1957537518 @default.
- W2063777990 cites W1964842789 @default.
- W2063777990 cites W1965398762 @default.
- W2063777990 cites W1967266848 @default.
- W2063777990 cites W1968814677 @default.
- W2063777990 cites W1971361773 @default.
- W2063777990 cites W1971637651 @default.
- W2063777990 cites W1971908211 @default.
- W2063777990 cites W1972931798 @default.
- W2063777990 cites W1973199949 @default.
- W2063777990 cites W1973965625 @default.
- W2063777990 cites W1974486772 @default.
- W2063777990 cites W1977608747 @default.
- W2063777990 cites W1980935526 @default.
- W2063777990 cites W1981964452 @default.
- W2063777990 cites W1983224547 @default.
- W2063777990 cites W1984486504 @default.
- W2063777990 cites W1984657399 @default.
- W2063777990 cites W1984903682 @default.
- W2063777990 cites W1986785442 @default.
- W2063777990 cites W1988917700 @default.
- W2063777990 cites W1991186595 @default.
- W2063777990 cites W1993876642 @default.
- W2063777990 cites W1995057778 @default.
- W2063777990 cites W1996548067 @default.
- W2063777990 cites W1999012962 @default.
- W2063777990 cites W1999028040 @default.
- W2063777990 cites W2002076761 @default.
- W2063777990 cites W2002654625 @default.
- W2063777990 cites W2003363988 @default.
- W2063777990 cites W2005811564 @default.
- W2063777990 cites W2006061341 @default.
- W2063777990 cites W2007000374 @default.
- W2063777990 cites W2011184409 @default.
- W2063777990 cites W2011643484 @default.
- W2063777990 cites W2012745344 @default.
- W2063777990 cites W2016420942 @default.
- W2063777990 cites W2017223857 @default.
- W2063777990 cites W2017515991 @default.
- W2063777990 cites W2021949777 @default.
- W2063777990 cites W2029275361 @default.
- W2063777990 cites W2030624761 @default.
- W2063777990 cites W2036452124 @default.
- W2063777990 cites W2039649228 @default.
- W2063777990 cites W2040020188 @default.
- W2063777990 cites W2041165226 @default.
- W2063777990 cites W2042260090 @default.
- W2063777990 cites W2042511952 @default.
- W2063777990 cites W2043395027 @default.
- W2063777990 cites W2043803403 @default.
- W2063777990 cites W2048281880 @default.
- W2063777990 cites W2049652135 @default.
- W2063777990 cites W2049926072 @default.
- W2063777990 cites W2049951334 @default.
- W2063777990 cites W2051316659 @default.
- W2063777990 cites W2051389226 @default.
- W2063777990 cites W2058554631 @default.
- W2063777990 cites W2059938714 @default.
- W2063777990 cites W2062005942 @default.
- W2063777990 cites W2065337934 @default.
- W2063777990 cites W2067626539 @default.
- W2063777990 cites W2069746327 @default.
- W2063777990 cites W2074664341 @default.
- W2063777990 cites W2076529943 @default.
- W2063777990 cites W2077673188 @default.
- W2063777990 cites W2081350964 @default.
- W2063777990 cites W2082783596 @default.
- W2063777990 cites W2087454918 @default.
- W2063777990 cites W2088988430 @default.
- W2063777990 cites W2089478514 @default.