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• W2063780304 abstract "Investigation of an extract of the Australian marine sponge Psammoclema sp. for dynamin I inhibitory activity led to the isolation of four new trihydroxysterols (1−4) related to aragusterol G. These compounds were largely identified by 1D and 2D NMR spectroscopic methods. While 1 was found to be inactive in the dynamin bioassay, bioassays did reveal that compounds 1−4 inhibited the growth of colorectal, breast, ovarian, and prostate cancer cell lines (GI50 5−27 μM). The additional insight that these new compounds give to previous SAR studies is discussed briefly." @default.
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• W2063780304 date "2009-01-08" @default.
• W2063780304 modified "2023-10-10" @default.
• W2063780304 title "Steroids from an Australian Sponge <i>Psammoclema</i> sp." @default.
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• W2063780304 doi "https://doi.org/10.1021/np800688f" @default.
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