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- W2063792561 abstract "It is generally accepted that glutamate serves as the neurotransmitter at most excitatory synapses in the mammalian central nervous system (CNS). Synaptic release of glutamate may trigger a fast and a slow excitatory postsynaptic current (EPSC). The slow EPSC is mediated by N-methyl-D-aspartate (NMDA) receptor channels, whereas the fast EPSC is mediated by non-NMDA receptor channels. The nootropic agent aniracetam selectively and reversibly slows the desensitization kinetics of non-NMDA channels and lengthens their single-channel open times. Aniracetam also modulates the kinetics of the fast EPSC in a manner that mirrors its action on the kinetics of the non-NMDA channels. These results support the hypothesis that the properties of the non-NMDA glutamate channels rather than the rate of neurotransmitter clearance are the primary determinants of the kinetics of the fast EPSC in the mammalian CNS." @default.
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- W2063792561 date "1991-10-11" @default.
- W2063792561 modified "2023-10-14" @default.
- W2063792561 title "Modulation of the Time Course of Fast EPSCs and Glutamate Channel Kinetics by Aniracetam" @default.
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- W2063792561 doi "https://doi.org/10.1126/science.1681589" @default.
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