Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063800518> ?p ?o ?g. }
- W2063800518 endingPage "1063" @default.
- W2063800518 startingPage "1053" @default.
- W2063800518 abstract "Hemoglobin digestion is an essential process for blood-feeding parasites. Using chemical tools, we deconvoluted the intracellular hemoglobinolytic cascade in the tick Ixodes ricinus, a vector of Lyme disease and tick-borne encephalitis. In tick gut tissue, a network of peptidases was demonstrated through imaging with specific activity-based probes and activity profiling with peptidic substrates and inhibitors. This peptidase network is induced upon blood feeding and degrades hemoglobin at acidic pH. Selective inhibitors were applied to dissect the roles of the individual peptidases and to determine the peptidase-specific cleavage map of the hemoglobin molecule. The degradation pathway is initiated by endopeptidases of aspartic and cysteine class (cathepsin D supported by cathepsin L and legumain) and is continued by cysteine amino- and carboxy-dipeptidases (cathepsins C and B). The identified enzymes are potential targets to developing novel anti-tick vaccines." @default.
- W2063800518 created "2016-06-24" @default.
- W2063800518 creator A5002435883 @default.
- W2063800518 creator A5005853846 @default.
- W2063800518 creator A5015834562 @default.
- W2063800518 creator A5016211348 @default.
- W2063800518 creator A5022335632 @default.
- W2063800518 creator A5031295914 @default.
- W2063800518 creator A5048776248 @default.
- W2063800518 creator A5049132537 @default.
- W2063800518 creator A5067990890 @default.
- W2063800518 creator A5069532325 @default.
- W2063800518 creator A5073043869 @default.
- W2063800518 date "2009-10-01" @default.
- W2063800518 modified "2023-10-17" @default.
- W2063800518 title "Hemoglobin Digestion in Blood-Feeding Ticks: Mapping a Multipeptidase Pathway by Functional Proteomics" @default.
- W2063800518 cites W1019036297 @default.
- W2063800518 cites W1484675846 @default.
- W2063800518 cites W1530238672 @default.
- W2063800518 cites W1530246363 @default.
- W2063800518 cites W1812339273 @default.
- W2063800518 cites W1904255855 @default.
- W2063800518 cites W1942210171 @default.
- W2063800518 cites W1971199972 @default.
- W2063800518 cites W1977390598 @default.
- W2063800518 cites W1984525000 @default.
- W2063800518 cites W1991032754 @default.
- W2063800518 cites W1999523024 @default.
- W2063800518 cites W2000315526 @default.
- W2063800518 cites W2004381546 @default.
- W2063800518 cites W2005941445 @default.
- W2063800518 cites W2012845953 @default.
- W2063800518 cites W2019427729 @default.
- W2063800518 cites W2026723999 @default.
- W2063800518 cites W2033240274 @default.
- W2063800518 cites W2035182991 @default.
- W2063800518 cites W2037391785 @default.
- W2063800518 cites W2038178479 @default.
- W2063800518 cites W2045775374 @default.
- W2063800518 cites W2046431841 @default.
- W2063800518 cites W2048160714 @default.
- W2063800518 cites W2055155126 @default.
- W2063800518 cites W2062123506 @default.
- W2063800518 cites W2064966683 @default.
- W2063800518 cites W2067040033 @default.
- W2063800518 cites W2071429505 @default.
- W2063800518 cites W2071738080 @default.
- W2063800518 cites W2075774945 @default.
- W2063800518 cites W2078964667 @default.
- W2063800518 cites W2082569440 @default.
- W2063800518 cites W2087845278 @default.
- W2063800518 cites W2089488835 @default.
- W2063800518 cites W2090982370 @default.
- W2063800518 cites W2091879499 @default.
- W2063800518 cites W2095290410 @default.
- W2063800518 cites W2095560211 @default.
- W2063800518 cites W2096244860 @default.
- W2063800518 cites W2099069196 @default.
- W2063800518 cites W2104246038 @default.
- W2063800518 cites W2105606854 @default.
- W2063800518 cites W2110761434 @default.
- W2063800518 cites W2111984757 @default.
- W2063800518 cites W2113417661 @default.
- W2063800518 cites W2127112944 @default.
- W2063800518 cites W2129514462 @default.
- W2063800518 cites W2135298082 @default.
- W2063800518 cites W2157318523 @default.
- W2063800518 cites W2158266834 @default.
- W2063800518 cites W2162870507 @default.
- W2063800518 doi "https://doi.org/10.1016/j.chembiol.2009.09.009" @default.
- W2063800518 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2801564" @default.
- W2063800518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19875079" @default.
- W2063800518 hasPublicationYear "2009" @default.
- W2063800518 type Work @default.
- W2063800518 sameAs 2063800518 @default.
- W2063800518 citedByCount "149" @default.
- W2063800518 countsByYear W20638005182012 @default.
- W2063800518 countsByYear W20638005182013 @default.
- W2063800518 countsByYear W20638005182014 @default.
- W2063800518 countsByYear W20638005182015 @default.
- W2063800518 countsByYear W20638005182016 @default.
- W2063800518 countsByYear W20638005182017 @default.
- W2063800518 countsByYear W20638005182018 @default.
- W2063800518 countsByYear W20638005182019 @default.
- W2063800518 countsByYear W20638005182020 @default.
- W2063800518 countsByYear W20638005182021 @default.
- W2063800518 countsByYear W20638005182022 @default.
- W2063800518 countsByYear W20638005182023 @default.
- W2063800518 crossrefType "journal-article" @default.
- W2063800518 hasAuthorship W2063800518A5002435883 @default.
- W2063800518 hasAuthorship W2063800518A5005853846 @default.
- W2063800518 hasAuthorship W2063800518A5015834562 @default.
- W2063800518 hasAuthorship W2063800518A5016211348 @default.
- W2063800518 hasAuthorship W2063800518A5022335632 @default.
- W2063800518 hasAuthorship W2063800518A5031295914 @default.
- W2063800518 hasAuthorship W2063800518A5048776248 @default.
- W2063800518 hasAuthorship W2063800518A5049132537 @default.
- W2063800518 hasAuthorship W2063800518A5067990890 @default.