Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063803225> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2063803225 endingPage "2674" @default.
- W2063803225 startingPage "2669" @default.
- W2063803225 abstract "Various peripheral human tissues express receptors for growth hormone secretagogue (GHS), the highest density being in the myocardium. It was also reported that some octapeptide analogs of somatostatin (SRIH) can displace radiolabeled Tyr-Ala-hexarelin from GHS receptors on the human pituitary and heart. Thus, it is possible that radionuclide analogs of SRIH such as OctreoScan and recently developed cytotoxic SRIH analogs containing doxorubicin (DOX) intended for targeted tumor therapy, could bind to these GHS receptors, compromising the safety of compounds of this type. Therefore, we determined the binding of OctreoScan and two cytotoxic SRIH analogs consisting of octapeptide carrier RC-121 and DOX (AN-162) or 2-pyrrolino-DOX (AN-238) to human myocardium specimens. None of these compounds displayed specific binding to the human heart indicating that the clinical use of SRIH analogs linked to anthracyclines or radionuclides should not be associated with increased cardiac side effects." @default.
- W2063803225 created "2016-06-24" @default.
- W2063803225 creator A5008707617 @default.
- W2063803225 creator A5020268469 @default.
- W2063803225 creator A5033107299 @default.
- W2063803225 creator A5063296502 @default.
- W2063803225 creator A5068739269 @default.
- W2063803225 date "2003-04-01" @default.
- W2063803225 modified "2023-09-27" @default.
- W2063803225 title "Absence of binding of targeted analogs of somatostatin carrying cytotoxic radicals or radionuclides to growth hormone secretagogue receptors on human myocardium" @default.
- W2063803225 cites W1979654732 @default.
- W2063803225 cites W1982635258 @default.
- W2063803225 cites W1995054939 @default.
- W2063803225 cites W1998767852 @default.
- W2063803225 cites W2002369153 @default.
- W2063803225 cites W2005674134 @default.
- W2063803225 cites W2033964870 @default.
- W2063803225 cites W2034531422 @default.
- W2063803225 cites W2043813981 @default.
- W2063803225 cites W2065361341 @default.
- W2063803225 cites W2128302079 @default.
- W2063803225 cites W2149074941 @default.
- W2063803225 cites W4232635880 @default.
- W2063803225 cites W4251599947 @default.
- W2063803225 cites W4252489788 @default.
- W2063803225 doi "https://doi.org/10.1016/s0024-3205(03)00181-4" @default.
- W2063803225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12672512" @default.
- W2063803225 hasPublicationYear "2003" @default.
- W2063803225 type Work @default.
- W2063803225 sameAs 2063803225 @default.
- W2063803225 citedByCount "3" @default.
- W2063803225 crossrefType "journal-article" @default.
- W2063803225 hasAuthorship W2063803225A5008707617 @default.
- W2063803225 hasAuthorship W2063803225A5020268469 @default.
- W2063803225 hasAuthorship W2063803225A5033107299 @default.
- W2063803225 hasAuthorship W2063803225A5063296502 @default.
- W2063803225 hasAuthorship W2063803225A5068739269 @default.
- W2063803225 hasConcept C126322002 @default.
- W2063803225 hasConcept C134018914 @default.
- W2063803225 hasConcept C154317977 @default.
- W2063803225 hasConcept C170493617 @default.
- W2063803225 hasConcept C185592680 @default.
- W2063803225 hasConcept C202751555 @default.
- W2063803225 hasConcept C2776297358 @default.
- W2063803225 hasConcept C2776694085 @default.
- W2063803225 hasConcept C2780161494 @default.
- W2063803225 hasConcept C2781303535 @default.
- W2063803225 hasConcept C55493867 @default.
- W2063803225 hasConcept C71924100 @default.
- W2063803225 hasConcept C80115893 @default.
- W2063803225 hasConcept C86803240 @default.
- W2063803225 hasConcept C98274493 @default.
- W2063803225 hasConceptScore W2063803225C126322002 @default.
- W2063803225 hasConceptScore W2063803225C134018914 @default.
- W2063803225 hasConceptScore W2063803225C154317977 @default.
- W2063803225 hasConceptScore W2063803225C170493617 @default.
- W2063803225 hasConceptScore W2063803225C185592680 @default.
- W2063803225 hasConceptScore W2063803225C202751555 @default.
- W2063803225 hasConceptScore W2063803225C2776297358 @default.
- W2063803225 hasConceptScore W2063803225C2776694085 @default.
- W2063803225 hasConceptScore W2063803225C2780161494 @default.
- W2063803225 hasConceptScore W2063803225C2781303535 @default.
- W2063803225 hasConceptScore W2063803225C55493867 @default.
- W2063803225 hasConceptScore W2063803225C71924100 @default.
- W2063803225 hasConceptScore W2063803225C80115893 @default.
- W2063803225 hasConceptScore W2063803225C86803240 @default.
- W2063803225 hasConceptScore W2063803225C98274493 @default.
- W2063803225 hasIssue "23" @default.
- W2063803225 hasLocation W20638032251 @default.
- W2063803225 hasLocation W20638032252 @default.
- W2063803225 hasOpenAccess W2063803225 @default.
- W2063803225 hasPrimaryLocation W20638032251 @default.
- W2063803225 hasRelatedWork W1536083272 @default.
- W2063803225 hasRelatedWork W1980503915 @default.
- W2063803225 hasRelatedWork W1990664757 @default.
- W2063803225 hasRelatedWork W2083683535 @default.
- W2063803225 hasRelatedWork W2089086068 @default.
- W2063803225 hasRelatedWork W2092061868 @default.
- W2063803225 hasRelatedWork W2118753359 @default.
- W2063803225 hasRelatedWork W2120244931 @default.
- W2063803225 hasRelatedWork W2169923476 @default.
- W2063803225 hasRelatedWork W2304724679 @default.
- W2063803225 hasVolume "72" @default.
- W2063803225 isParatext "false" @default.
- W2063803225 isRetracted "false" @default.
- W2063803225 magId "2063803225" @default.
- W2063803225 workType "article" @default.