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• W2063804593 abstract "Angiotensin converting enzyme (ACE) has been purified from rat lung and an antibody produced in sheep. The antibody blocks ACE activity both in lung extracts and in rat serum and, to a lesser extent, in human serum. In immunoelectrophoresis of human serum or lung ACE, the antibody produces a single precipitin band in the β-globulin region. By immunofluorescence, the antibody stains vascular intimal surfaces and interstitial capillaries in the lung and glomerular capillary loops of the kidney. When IgG rich in anti-ACE activity and IgG obtained from normal sheep are radiolabeled and injected into rats, preferential localization of the former is found in the lung, irrespective of whether the IgG preparations are injected into a foot vein or into the aortic arch. The fixation of antibody to ACE within the lung is associated with a significant increase in vascular permeability, which requires complement, suggesting that anti-ACE inflicts vascular injury in the lung in a complement-dependent manner. Higher doses of anti-ACE cause death within an hour of injection. This phenomenon is also complement dependent. These findings indicate that antibody to ACE causes pulmonary injury that is probably a result of complement fixing complexes forming on the surfaces of pulmonary endothelial cells." @default.
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• W2063804593 date "1980-03-01" @default.
• W2063804593 modified "2023-09-28" @default.
• W2063804593 title "In vitro and in vivo effects of antibody to rat angiotensin converting enzyme" @default.
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• W2063804593 doi "https://doi.org/10.1016/0090-1229(80)90056-2" @default.
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