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- W2063804865 abstract "IN THE two and one-half years since Mackenzie, Mackenzie, and McCollum (1) and Richter and Clisby (2) reported a striking goitrogenic action in animals as a result of the administration of sulfaguanidine and of phenyl-thiourea, respectively, no less than 51 articles have been devoted to a study of a number of aniline and thiourea derivatives of relatively low toxicity, which are capable of depressing the formation of thyroglobulin (3 to 53). A critically detailed analysis of the work covered by these communications is far outside the scope of the present report. However, several generally accepted facts emerge which may justify reiteration. 1. “Thyroid-active” sulfonamide and thiourea derivatives depress metabolism. 2. These compounds produce an enlargement and hyperplasia of the thyroid in animals and a hyperplasia in man. 3. The degree of hyperplasia may be quantitatively expressed through variations in the height of the follicular cell (20, 21, 37)." @default.
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- W2063804865 date "1944-06-01" @default.
- W2063804865 modified "2023-09-25" @default.
- W2063804865 title "The Treatment of 26 Thyrotoxic Patients with Thiouracil and a Review of Toxic Reactions in All (135) Reported Cases" @default.
- W2063804865 doi "https://doi.org/10.1210/jcem-4-6-249" @default.
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