Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063805004> ?p ?o ?g. }
- W2063805004 endingPage "e193" @default.
- W2063805004 startingPage "e193" @default.
- W2063805004 abstract "Cas9 is an RNA-guided double-stranded DNA nuclease that participates in clustered regularly interspaced short palindromic repeats (CRISPR)-mediated adaptive immunity in prokaryotes. CRISPR–Cas9 has recently been used to generate insertion and deletion mutations in Caenorhabditis elegans, but not to create tailored changes (knock-ins). We show that the CRISPR–CRISPR-associated (Cas) system can be adapted for efficient and precise editing of the C. elegans genome. The targeted double-strand breaks generated by CRISPR are substrates for transgene-instructed gene conversion. This allows customized changes in the C. elegans genome by homologous recombination: sequences contained in the repair template (the transgene) are copied by gene conversion into the genome. The possibility to edit the C. elegans genome at selected locations will facilitate the systematic study of gene function in this widely used model organism." @default.
- W2063805004 created "2016-06-24" @default.
- W2063805004 creator A5025967547 @default.
- W2063805004 creator A5046111835 @default.
- W2063805004 creator A5083051669 @default.
- W2063805004 date "2013-09-05" @default.
- W2063805004 modified "2023-10-01" @default.
- W2063805004 title "Efficient genome editing in Caenorhabditis elegans by CRISPR-targeted homologous recombination" @default.
- W2063805004 cites W1906155566 @default.
- W2063805004 cites W1966272997 @default.
- W2063805004 cites W1976019826 @default.
- W2063805004 cites W1976391205 @default.
- W2063805004 cites W1988884282 @default.
- W2063805004 cites W1990211095 @default.
- W2063805004 cites W1993834457 @default.
- W2063805004 cites W2000046950 @default.
- W2063805004 cites W2001488804 @default.
- W2063805004 cites W2003171404 @default.
- W2063805004 cites W2015713400 @default.
- W2063805004 cites W2015911939 @default.
- W2063805004 cites W2017797880 @default.
- W2063805004 cites W2019670881 @default.
- W2063805004 cites W2025730748 @default.
- W2063805004 cites W2029355706 @default.
- W2063805004 cites W2032002636 @default.
- W2063805004 cites W2041797639 @default.
- W2063805004 cites W2045435533 @default.
- W2063805004 cites W2047032063 @default.
- W2063805004 cites W2047454656 @default.
- W2063805004 cites W2063148079 @default.
- W2063805004 cites W2064815984 @default.
- W2063805004 cites W2080064417 @default.
- W2063805004 cites W2082131511 @default.
- W2063805004 cites W2092058453 @default.
- W2063805004 cites W2101058219 @default.
- W2063805004 cites W2120003242 @default.
- W2063805004 cites W2122163057 @default.
- W2063805004 cites W2133702185 @default.
- W2063805004 cites W2138993899 @default.
- W2063805004 cites W2153344788 @default.
- W2063805004 cites W2163259891 @default.
- W2063805004 cites W959762504 @default.
- W2063805004 doi "https://doi.org/10.1093/nar/gkt805" @default.
- W2063805004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3814388" @default.
- W2063805004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24013562" @default.
- W2063805004 hasPublicationYear "2013" @default.
- W2063805004 type Work @default.
- W2063805004 sameAs 2063805004 @default.
- W2063805004 citedByCount "126" @default.
- W2063805004 countsByYear W20638050042013 @default.
- W2063805004 countsByYear W20638050042014 @default.
- W2063805004 countsByYear W20638050042015 @default.
- W2063805004 countsByYear W20638050042016 @default.
- W2063805004 countsByYear W20638050042017 @default.
- W2063805004 countsByYear W20638050042018 @default.
- W2063805004 countsByYear W20638050042019 @default.
- W2063805004 countsByYear W20638050042020 @default.
- W2063805004 countsByYear W20638050042021 @default.
- W2063805004 countsByYear W20638050042022 @default.
- W2063805004 countsByYear W20638050042023 @default.
- W2063805004 crossrefType "journal-article" @default.
- W2063805004 hasAuthorship W2063805004A5025967547 @default.
- W2063805004 hasAuthorship W2063805004A5046111835 @default.
- W2063805004 hasAuthorship W2063805004A5083051669 @default.
- W2063805004 hasBestOaLocation W20638050041 @default.
- W2063805004 hasConcept C102230213 @default.
- W2063805004 hasConcept C102744134 @default.
- W2063805004 hasConcept C104317684 @default.
- W2063805004 hasConcept C132455925 @default.
- W2063805004 hasConcept C141231307 @default.
- W2063805004 hasConcept C144501496 @default.
- W2063805004 hasConcept C2776496032 @default.
- W2063805004 hasConcept C2778944004 @default.
- W2063805004 hasConcept C44667518 @default.
- W2063805004 hasConcept C54355233 @default.
- W2063805004 hasConcept C552990157 @default.
- W2063805004 hasConcept C70721500 @default.
- W2063805004 hasConcept C86803240 @default.
- W2063805004 hasConcept C98108389 @default.
- W2063805004 hasConceptScore W2063805004C102230213 @default.
- W2063805004 hasConceptScore W2063805004C102744134 @default.
- W2063805004 hasConceptScore W2063805004C104317684 @default.
- W2063805004 hasConceptScore W2063805004C132455925 @default.
- W2063805004 hasConceptScore W2063805004C141231307 @default.
- W2063805004 hasConceptScore W2063805004C144501496 @default.
- W2063805004 hasConceptScore W2063805004C2776496032 @default.
- W2063805004 hasConceptScore W2063805004C2778944004 @default.
- W2063805004 hasConceptScore W2063805004C44667518 @default.
- W2063805004 hasConceptScore W2063805004C54355233 @default.
- W2063805004 hasConceptScore W2063805004C552990157 @default.
- W2063805004 hasConceptScore W2063805004C70721500 @default.
- W2063805004 hasConceptScore W2063805004C86803240 @default.
- W2063805004 hasConceptScore W2063805004C98108389 @default.
- W2063805004 hasIssue "20" @default.
- W2063805004 hasLocation W20638050041 @default.
- W2063805004 hasLocation W20638050042 @default.
- W2063805004 hasLocation W20638050043 @default.
- W2063805004 hasLocation W20638050044 @default.