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- W2063817488 abstract "In humans, varying amounts of absorbed β-carotene are oxidatively cleaved by the enzyme β,β-carotene 15,15'-monooxygenase 1 (BCMO1) into two molecules of all-trans-retinal. The other carotenoid cleavage enzyme β,β-carotene 9',10'-dioxygenase (BCDO2) cleaves β-carotene at the 9',10' double bond forming β-apo-10'-carotenal and β-ionone. Although the contribution of BCDO2 to vitamin A formation has long been debated, BCMO1 is currently considered the key enzyme for retinoid metabolism. Furthermore, BCMO1 has limited enzyme activity towards carotenoids other than provitamin A carotenoids, whereas BCDO2 exhibits a broader specificity. Both enzymes are located at different sites within the cell, with BCMO1 being a cytosolic protein and BCDO2 being located in the mitochondria. Expression of BCMO1 in tissues other than the intestine has recently revealed its function for tissue-specific retinoid metabolism with importance in embryogenesis and lipid metabolism. On the other hand, biological activity of BCDO2 metabolites has been shown to be important in protecting against carotenoid-induced mitochondrial dysfunction. Single-nucleotide polymorphisms (SNPs) such as R267S and A379V in BCMO1 can partly explain inter-individual variations observed in carotenoid metabolism. Advancing knowledge about the physiological role of these two enzymes will contribute to understanding the importance of carotenoids in health and disease." @default.
- W2063817488 created "2016-06-24" @default.
- W2063817488 creator A5017923277 @default.
- W2063817488 creator A5031342188 @default.
- W2063817488 creator A5032685055 @default.
- W2063817488 creator A5057872751 @default.
- W2063817488 date "2012-02-01" @default.
- W2063817488 modified "2023-09-24" @default.
- W2063817488 title "Importance of β,β-carotene 15,15′-monooxygenase 1 (BCMO1) and β,β-carotene 9′,10′-dioxygenase 2 (BCDO2) in nutrition and health" @default.
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- W2063817488 doi "https://doi.org/10.1002/mnfr.201100387" @default.
- W2063817488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22147584" @default.
- W2063817488 hasPublicationYear "2012" @default.
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