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- W2063844035 abstract "The effects of two barbiturates (phenobarbitone and pentobarbitone) and one benzodiazepine (chlordiazepoxide) were studied on uptake, retention and spontaneous and stimulation-induced release of 3H-noradrenaline in rat cerebral cortex slices in vitro. The drugs, in a wide range of concentrations, did not interfere with the uptake and retention of 3H-noradrenaIine nor did they change the spontaneous release when slices, preincubated with 3H-noradrenaline, were rinsed together with the drug. The field stimulation-induced release of 3H-noradrenaline was also unaffected by these drugs. Pentobarbitone did not affect the amphetamine-induced release of 3H-noradrenaline from the slices. Previous findings show that barbiturates and benzodiazepines decrease the turnover of noradrenaline in the cerebral cortex. The present results make it improbable that this turnover effect is mediated via a direct effect of the drugs on the noradrenaline nerve terminals." @default.
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- W2063844035 date "1973-11-01" @default.
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- W2063844035 title "Uptake and release of noradrenaline in rat cerebral cortex in vitro: No effect of benzodiazepines and barbiturates" @default.
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- W2063844035 doi "https://doi.org/10.1016/0028-3908(73)90053-1" @default.
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