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- W2063846127 abstract "<h3>Background</h3> There are few long-term studies of the effects of treatment on the natural course of asthma. <h3>Objective</h3> To investigate the longitudinal changes in airflow limitation and airway hyperresponsiveness (AHR) in asthma. <h3>Methods</h3> We recruited 81 outpatients (never smokers) with stable asthma from the Kyoto University Hospital. They were evaluated for pulmonary function and AHR, expressed by forced expiratory volume in 1 second (FEV<sub>1</sub>) and the provocation dose that caused a 20% fall in FEV<sub>1</sub> (PD<sub>20</sub>-FEV<sub>1</sub>), respectively, at entry and every 6 months over 3 years. We used random effects models to estimate the slopes of these changes, and then evaluated the relationship between these changes and their predictive factors. <h3>Results</h3> Using random effects models, the percentage of the predicted FEV<sub>1</sub> (%FEV<sub>1</sub>) declined significantly but slightly at a mean rate of 0.5%/year (<i>P</i> = 0.002; 95% confidence interval, 0.3 to 0.8). The mean decline rate of FEV<sub>1</sub> was 34 mL/year. However, Log(PD<sub>20</sub>-FEV<sub>1</sub>) showed significant improvement at a mean rate of 0.088 cumulative units/year (<i>P</i> < 0.001; 95% confidence interval, 0.053 to 0.122). Multiple regression analysis showed that the baseline values of %FEV<sub>1</sub> and Log(PD<sub>20</sub>-FEV<sub>1</sub>) were the most significant predictive factors for their subsequent changes, respectively. <h3>Conclusions</h3> In stable asthmatic patients treated according to international guidelines, airflow limitation progressed at a nearly normal rate over 3 years. However, AHR continued to improve despite its ceiling effects. Multiple regression analysis revealed a significant negative relationship between the initial values and the subsequent changes in airflow limitation and AHR, respectively." @default.
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- W2063846127 date "2002-12-01" @default.
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- W2063846127 title "Longitudinal changes in airflow limitation and airway hyperresponsiveness in patients with stable asthma" @default.
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- W2063846127 doi "https://doi.org/10.1016/s1081-1206(10)62111-4" @default.
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