FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063848897> ?p ?o ?g. }

• W2063848897 endingPage "75" @default.
• W2063848897 startingPage "69" @default.
• W2063848897 abstract "Cystic fibrosis (CF) disease severity is characterized by a broad variability that has been attributed, in addition to the CF transmembrane conductance regulator (CFTR) genotype, to modulating factors such as CFTR-mediated residual chloride (Cl-) secretion. Moreover, CFTR has been suggested to function as a receptor for Pseudomonas aeruginosa (PA). In this study, we investigated whether or not the presence of residual Cl- secretion protects against early chronic PA colonization of patients' airways. Excluding influences on the phenotype caused by different CFTR mutations, we evaluated a cohort of F508del homozygous individuals with respect to the correlation between residual Cl- secretion and the age of onset of PA colonization as an important marker of clinical phenotype. A group with early chronic PA colonization before the age of 7 y (n = 14) was compared with a cohort that had no initial PA detection at least until the age of 13 y (n = 10). We determined the Cl- transport properties by using the intestinal current measurement in rectal suction biopsies. Residual Cl- secretion, most likely due to the CFTR Cl- channel, was observed in 63% of subjects, more frequently in early chronically PA colonized than among late or not colonized patients. These results demonstrate the presence of some active F508del-CFTR in the apical cell membrane and imply that factors other than the CFTR-mediated residual Cl- secretion determine the age of onset of PA colonization." @default.
• W2063848897 created "2016-06-24" @default.
• W2063848897 creator A5000592091 @default.
• W2063848897 creator A5003789234 @default.
• W2063848897 creator A5009902878 @default.
• W2063848897 creator A5015555168 @default.
• W2063848897 creator A5040440040 @default.
• W2063848897 creator A5041981028 @default.
• W2063848897 creator A5058087541 @default.
• W2063848897 creator A5090138985 @default.
• W2063848897 date "2004-01-01" @default.
• W2063848897 modified "2023-10-04" @default.
• W2063848897 title "Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Mediated Residual Chloride Secretion Does Not Protect against Early Chronic Pseudomonas aeruginosa Infection in F508del Homozygous Cystic Fibrosis Patients" @default.
• W2063848897 cites W1598108391 @default.
• W2063848897 cites W1856243426 @default.
• W2063848897 cites W1887816242 @default.
• W2063848897 cites W1965180344 @default.
• W2063848897 cites W1975971473 @default.
• W2063848897 cites W1977911415 @default.
• W2063848897 cites W1978183357 @default.
• W2063848897 cites W1979220137 @default.
• W2063848897 cites W2000241372 @default.
• W2063848897 cites W2001213356 @default.
• W2063848897 cites W2005269914 @default.
• W2063848897 cites W2026440877 @default.
• W2063848897 cites W2028134905 @default.
• W2063848897 cites W2030500704 @default.
• W2063848897 cites W2033926035 @default.
• W2063848897 cites W2043569451 @default.
• W2063848897 cites W2044942738 @default.
• W2063848897 cites W2045803045 @default.
• W2063848897 cites W2053998870 @default.
• W2063848897 cites W2059232582 @default.
• W2063848897 cites W2065541938 @default.
• W2063848897 cites W2077620288 @default.
• W2063848897 cites W2085236767 @default.
• W2063848897 cites W2086309846 @default.
• W2063848897 cites W2099222122 @default.
• W2063848897 cites W2111616620 @default.
• W2063848897 cites W2121146879 @default.
• W2063848897 cites W2122530389 @default.
• W2063848897 cites W2128734935 @default.
• W2063848897 cites W2136054055 @default.
• W2063848897 cites W2141626158 @default.
• W2063848897 cites W2142443730 @default.
• W2063848897 cites W2144661980 @default.
• W2063848897 cites W2151589932 @default.
• W2063848897 cites W2165257594 @default.
• W2063848897 cites W2171710608 @default.
• W2063848897 cites W2187516635 @default.
• W2063848897 cites W2320394900 @default.
• W2063848897 cites W2327703579 @default.
• W2063848897 cites W2402530611 @default.
• W2063848897 doi "https://doi.org/10.1203/01.pdr.0000100758.66805.ce" @default.
• W2063848897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14605249" @default.
• W2063848897 hasPublicationYear "2004" @default.
• W2063848897 type Work @default.
• W2063848897 sameAs 2063848897 @default.
• W2063848897 citedByCount "18" @default.
• W2063848897 countsByYear W20638488972014 @default.
• W2063848897 countsByYear W20638488972015 @default.
• W2063848897 countsByYear W20638488972017 @default.
• W2063848897 countsByYear W20638488972022 @default.
• W2063848897 countsByYear W20638488972023 @default.
• W2063848897 crossrefType "journal-article" @default.
• W2063848897 hasAuthorship W2063848897A5000592091 @default.
• W2063848897 hasAuthorship W2063848897A5003789234 @default.
• W2063848897 hasAuthorship W2063848897A5009902878 @default.
• W2063848897 hasAuthorship W2063848897A5015555168 @default.
• W2063848897 hasAuthorship W2063848897A5040440040 @default.
• W2063848897 hasAuthorship W2063848897A5041981028 @default.
• W2063848897 hasAuthorship W2063848897A5058087541 @default.
• W2063848897 hasAuthorship W2063848897A5090138985 @default.
• W2063848897 hasBestOaLocation W20638488971 @default.
• W2063848897 hasConcept C104317684 @default.
• W2063848897 hasConcept C126322002 @default.
• W2063848897 hasConcept C127716648 @default.
• W2063848897 hasConcept C135763542 @default.
• W2063848897 hasConcept C145822097 @default.
• W2063848897 hasConcept C185592680 @default.
• W2063848897 hasConcept C2776927270 @default.
• W2063848897 hasConcept C2776938444 @default.
• W2063848897 hasConcept C2777637488 @default.
• W2063848897 hasConcept C2778428886 @default.
• W2063848897 hasConcept C49039625 @default.
• W2063848897 hasConcept C523546767 @default.
• W2063848897 hasConcept C54355233 @default.
• W2063848897 hasConcept C55493867 @default.
• W2063848897 hasConcept C71924100 @default.
• W2063848897 hasConcept C86803240 @default.
• W2063848897 hasConcept C89423630 @default.
• W2063848897 hasConcept C90924648 @default.
• W2063848897 hasConceptScore W2063848897C104317684 @default.
• W2063848897 hasConceptScore W2063848897C126322002 @default.
• W2063848897 hasConceptScore W2063848897C127716648 @default.
• W2063848897 hasConceptScore W2063848897C135763542 @default.
• W2063848897 hasConceptScore W2063848897C145822097 @default.
• W2063848897 hasConceptScore W2063848897C185592680 @default.

• next