FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063852759> ?p ?o ?g. }

• W2063852759 endingPage "562" @default.
• W2063852759 startingPage "556" @default.
• W2063852759 abstract "Background The criteria commonly used for prognosis of colorectal cancer remain histoprognostic and are based on primarily TNM classification. The lack of discrimination of purely histoprognostic criteria is evidenced by the development of different outcomes in similarly staged patients. The aim of this work was to study the long-term prognostic value of preoperative detection of circulating enterocytes in the blood of colorectal cancer patients using the CGM2 reverse transcriptase-polymerase chain reaction (RT-PCR) assay. Methods A nested RT-PCR with specific primers for CGM2 was used preoperatively to detect circulating enterocytes in 121 patients (64 men, 57 women; mean age, 70 years) with colorectal neoplasms. Results Circulating enterocytes were detected in 58/121 (48%) patients. The positivity rate was not correlated with American Joint Committee on Cancer (AJCC) staging (stage I, 11/28 (39%); stage II, 13/34 (38%); stage III, 15/23 (65%); stage IV, 17/32 (53%); sterilized (after radiotherapy, no residual neoplasm) 2/4 (50%); not significant [NS]), but circulating enterocytes were detected more frequently in patients with metastatic lymph nodes (60% vs 41%, P = .06). Overall 5-year survival rates (mean ± SD) were 40 ± 13% and 45 ± 13% for patients without and with circulating enterocytes, respectively (P = NS). Similarly, recurrence-free survival rates were 71 ± 4% versus 72 ± 14% (P = NS). Using univariate analysis, AJCC stage (P < .0001) was correlated with survival. AJCC stage (P = .007) and obstructive neoplasms (P = .043) were correlated with recurrence-free survival. Using multivariate analysis, AJCC stage was correlated with survival and recurrence-free survival. Conclusions Preoperative detection of circulating enterocytes using CGM2 RT-PCR assay provides no specific prognostic information and cannot be used as a decision criterion for adjuvant therapy. The criteria commonly used for prognosis of colorectal cancer remain histoprognostic and are based on primarily TNM classification. The lack of discrimination of purely histoprognostic criteria is evidenced by the development of different outcomes in similarly staged patients. The aim of this work was to study the long-term prognostic value of preoperative detection of circulating enterocytes in the blood of colorectal cancer patients using the CGM2 reverse transcriptase-polymerase chain reaction (RT-PCR) assay. A nested RT-PCR with specific primers for CGM2 was used preoperatively to detect circulating enterocytes in 121 patients (64 men, 57 women; mean age, 70 years) with colorectal neoplasms. Circulating enterocytes were detected in 58/121 (48%) patients. The positivity rate was not correlated with American Joint Committee on Cancer (AJCC) staging (stage I, 11/28 (39%); stage II, 13/34 (38%); stage III, 15/23 (65%); stage IV, 17/32 (53%); sterilized (after radiotherapy, no residual neoplasm) 2/4 (50%); not significant [NS]), but circulating enterocytes were detected more frequently in patients with metastatic lymph nodes (60% vs 41%, P = .06). Overall 5-year survival rates (mean ± SD) were 40 ± 13% and 45 ± 13% for patients without and with circulating enterocytes, respectively (P = NS). Similarly, recurrence-free survival rates were 71 ± 4% versus 72 ± 14% (P = NS). Using univariate analysis, AJCC stage (P < .0001) was correlated with survival. AJCC stage (P = .007) and obstructive neoplasms (P = .043) were correlated with recurrence-free survival. Using multivariate analysis, AJCC stage was correlated with survival and recurrence-free survival. Preoperative detection of circulating enterocytes using CGM2 RT-PCR assay provides no specific prognostic information and cannot be used as a decision criterion for adjuvant therapy." @default.
• W2063852759 created "2016-06-24" @default.
• W2063852759 creator A5001696300 @default.
• W2063852759 creator A5003738660 @default.
• W2063852759 creator A5008717441 @default.
• W2063852759 creator A5022247973 @default.
• W2063852759 creator A5048511315 @default.
• W2063852759 creator A5055997252 @default.
• W2063852759 creator A5065426259 @default.
• W2063852759 creator A5072054300 @default.
• W2063852759 creator A5081179224 @default.
• W2063852759 date "2006-04-01" @default.
• W2063852759 modified "2023-09-30" @default.
• W2063852759 title "Long-term prognostic value of detection of circulating colorectal cancer cells using CGM2 reverse transcriptase-polymerase chain reaction assay" @default.
• W2063852759 cites W1558416642 @default.
• W2063852759 cites W1966956809 @default.
• W2063852759 cites W1991076778 @default.
• W2063852759 cites W1993158708 @default.
• W2063852759 cites W1998947396 @default.
• W2063852759 cites W2001095490 @default.
• W2063852759 cites W2006085256 @default.
• W2063852759 cites W2009248007 @default.
• W2063852759 cites W201195939 @default.
• W2063852759 cites W2013607330 @default.
• W2063852759 cites W2015047172 @default.
• W2063852759 cites W2015415136 @default.
• W2063852759 cites W2019295221 @default.
• W2063852759 cites W2020072428 @default.
• W2063852759 cites W2040129015 @default.
• W2063852759 cites W2056507674 @default.
• W2063852759 cites W2063607526 @default.
• W2063852759 cites W2080590724 @default.
• W2063852759 cites W2084441169 @default.
• W2063852759 cites W2097425080 @default.
• W2063852759 cites W2101818435 @default.
• W2063852759 cites W2110425817 @default.
• W2063852759 cites W2122037371 @default.
• W2063852759 cites W2339671919 @default.
• W2063852759 cites W4234377402 @default.
• W2063852759 doi "https://doi.org/10.1016/j.surg.2005.09.025" @default.
• W2063852759 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16627067" @default.
• W2063852759 hasPublicationYear "2006" @default.
• W2063852759 type Work @default.
• W2063852759 sameAs 2063852759 @default.
• W2063852759 citedByCount "12" @default.
• W2063852759 countsByYear W20638527592013 @default.
• W2063852759 countsByYear W20638527592017 @default.
• W2063852759 countsByYear W20638527592019 @default.
• W2063852759 countsByYear W20638527592023 @default.
• W2063852759 crossrefType "journal-article" @default.
• W2063852759 hasAuthorship W2063852759A5001696300 @default.
• W2063852759 hasAuthorship W2063852759A5003738660 @default.
• W2063852759 hasAuthorship W2063852759A5008717441 @default.
• W2063852759 hasAuthorship W2063852759A5022247973 @default.
• W2063852759 hasAuthorship W2063852759A5048511315 @default.
• W2063852759 hasAuthorship W2063852759A5055997252 @default.
• W2063852759 hasAuthorship W2063852759A5065426259 @default.
• W2063852759 hasAuthorship W2063852759A5072054300 @default.
• W2063852759 hasAuthorship W2063852759A5081179224 @default.
• W2063852759 hasConcept C104317684 @default.
• W2063852759 hasConcept C121608353 @default.
• W2063852759 hasConcept C126322002 @default.
• W2063852759 hasConcept C142724271 @default.
• W2063852759 hasConcept C143998085 @default.
• W2063852759 hasConcept C144301174 @default.
• W2063852759 hasConcept C146357865 @default.
• W2063852759 hasConcept C151730666 @default.
• W2063852759 hasConcept C156719811 @default.
• W2063852759 hasConcept C2776283816 @default.
• W2063852759 hasConcept C2779720271 @default.
• W2063852759 hasConcept C38180746 @default.
• W2063852759 hasConcept C49105822 @default.
• W2063852759 hasConcept C526805850 @default.
• W2063852759 hasConcept C55493867 @default.
• W2063852759 hasConcept C71924100 @default.
• W2063852759 hasConcept C86803240 @default.
• W2063852759 hasConcept C90924648 @default.
• W2063852759 hasConceptScore W2063852759C104317684 @default.
• W2063852759 hasConceptScore W2063852759C121608353 @default.
• W2063852759 hasConceptScore W2063852759C126322002 @default.
• W2063852759 hasConceptScore W2063852759C142724271 @default.
• W2063852759 hasConceptScore W2063852759C143998085 @default.
• W2063852759 hasConceptScore W2063852759C144301174 @default.
• W2063852759 hasConceptScore W2063852759C146357865 @default.
• W2063852759 hasConceptScore W2063852759C151730666 @default.
• W2063852759 hasConceptScore W2063852759C156719811 @default.
• W2063852759 hasConceptScore W2063852759C2776283816 @default.
• W2063852759 hasConceptScore W2063852759C2779720271 @default.
• W2063852759 hasConceptScore W2063852759C38180746 @default.
• W2063852759 hasConceptScore W2063852759C49105822 @default.
• W2063852759 hasConceptScore W2063852759C526805850 @default.
• W2063852759 hasConceptScore W2063852759C55493867 @default.
• W2063852759 hasConceptScore W2063852759C71924100 @default.
• W2063852759 hasConceptScore W2063852759C86803240 @default.
• W2063852759 hasConceptScore W2063852759C90924648 @default.
• W2063852759 hasIssue "4" @default.
• W2063852759 hasLocation W20638527591 @default.
• W2063852759 hasLocation W20638527592 @default.

• next