Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063852893> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2063852893 endingPage "400" @default.
- W2063852893 startingPage "391" @default.
- W2063852893 abstract "The absorption spectra of polyadenylic acid (polyA) radicals in N20 saturated aqueous solution have been measured as a function of time (up to 15 s) following an 0.4μS electron pulse. The spectra and their changes were analysed by comparison with those from monomeric adenine derivatives (nucleosides and nucleotides) which had been studied by Steenken.1The reaction of OH· radicals with the adenine moiety in poly A results in the formation of two hvdroxvl adducts at the positions C-4 [polyA40H·] and C-8 [polyA80H·]. Each OH-adduct undergoes a unimol-ecular transformation reaction before any bimolecular or other unimolecular decay occurs. These reactions are characterized by different rate constants and pH dependencies. The polyA40H· adduct undergoes a dehydration reaction to yield a neutral N6 centered radical (rate constant Kdeh= 1.4 × 104s-1 at pH7.3). This reaction is strongly inhibited by H+. In comparison with the analogous reactions in adenosine phosphates, the kinetic pK value for its inhibition is two pH units higher. This shift is the result of the counter ion condensation or double-strand formation. The polyA80H· adduct undergoes an imidazole ring opening reaction to yield an enol type of formamidopyrimidine radical with the resulting base damage (kr.o. = 3.5 × 104 s -1 at pH7.3). This reaction in contrast is strongly catalysed by H+and OH-, similar as for adenosine but different compared to the nucleotides." @default.
- W2063852893 created "2016-06-24" @default.
- W2063852893 creator A5032781058 @default.
- W2063852893 creator A5042336596 @default.
- W2063852893 creator A5068622337 @default.
- W2063852893 date "1992-01-01" @default.
- W2063852893 modified "2023-10-14" @default.
- W2063852893 title "Hydroxyl Radical-Induced Reactions in Polyadenylic Acid as Studied by Pulse Radiolysis: Part I. Transformation Reactions of Two Isomeric OH-Adducts" @default.
- W2063852893 cites W1906610981 @default.
- W2063852893 cites W1973460237 @default.
- W2063852893 cites W1978161934 @default.
- W2063852893 cites W1981912201 @default.
- W2063852893 cites W1982729779 @default.
- W2063852893 cites W1993514197 @default.
- W2063852893 cites W1998127752 @default.
- W2063852893 cites W2010202988 @default.
- W2063852893 cites W2012815252 @default.
- W2063852893 cites W2030382154 @default.
- W2063852893 cites W2035823087 @default.
- W2063852893 cites W2040121959 @default.
- W2063852893 cites W2074687585 @default.
- W2063852893 cites W2075287733 @default.
- W2063852893 cites W2080502542 @default.
- W2063852893 cites W2111879600 @default.
- W2063852893 cites W2123475461 @default.
- W2063852893 cites W2144685193 @default.
- W2063852893 cites W2197178232 @default.
- W2063852893 cites W2198983321 @default.
- W2063852893 cites W2257926289 @default.
- W2063852893 cites W2280124809 @default.
- W2063852893 cites W2329339701 @default.
- W2063852893 cites W280694366 @default.
- W2063852893 cites W295406538 @default.
- W2063852893 cites W297399904 @default.
- W2063852893 cites W4319279 @default.
- W2063852893 doi "https://doi.org/10.3109/10715769209049189" @default.
- W2063852893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1325400" @default.
- W2063852893 hasPublicationYear "1992" @default.
- W2063852893 type Work @default.
- W2063852893 sameAs 2063852893 @default.
- W2063852893 citedByCount "6" @default.
- W2063852893 crossrefType "journal-article" @default.
- W2063852893 hasAuthorship W2063852893A5032781058 @default.
- W2063852893 hasAuthorship W2063852893A5042336596 @default.
- W2063852893 hasAuthorship W2063852893A5068622337 @default.
- W2063852893 hasConcept C108204754 @default.
- W2063852893 hasConcept C121332964 @default.
- W2063852893 hasConcept C134121241 @default.
- W2063852893 hasConcept C139066938 @default.
- W2063852893 hasConcept C148898269 @default.
- W2063852893 hasConcept C155647269 @default.
- W2063852893 hasConcept C178790620 @default.
- W2063852893 hasConcept C185592680 @default.
- W2063852893 hasConcept C191897082 @default.
- W2063852893 hasConcept C192562407 @default.
- W2063852893 hasConcept C62520636 @default.
- W2063852893 hasConcept C66887884 @default.
- W2063852893 hasConcept C75473681 @default.
- W2063852893 hasConcept C93391505 @default.
- W2063852893 hasConceptScore W2063852893C108204754 @default.
- W2063852893 hasConceptScore W2063852893C121332964 @default.
- W2063852893 hasConceptScore W2063852893C134121241 @default.
- W2063852893 hasConceptScore W2063852893C139066938 @default.
- W2063852893 hasConceptScore W2063852893C148898269 @default.
- W2063852893 hasConceptScore W2063852893C155647269 @default.
- W2063852893 hasConceptScore W2063852893C178790620 @default.
- W2063852893 hasConceptScore W2063852893C185592680 @default.
- W2063852893 hasConceptScore W2063852893C191897082 @default.
- W2063852893 hasConceptScore W2063852893C192562407 @default.
- W2063852893 hasConceptScore W2063852893C62520636 @default.
- W2063852893 hasConceptScore W2063852893C66887884 @default.
- W2063852893 hasConceptScore W2063852893C75473681 @default.
- W2063852893 hasConceptScore W2063852893C93391505 @default.
- W2063852893 hasIssue "6" @default.
- W2063852893 hasLocation W20638528931 @default.
- W2063852893 hasLocation W20638528932 @default.
- W2063852893 hasOpenAccess W2063852893 @default.
- W2063852893 hasPrimaryLocation W20638528931 @default.
- W2063852893 hasRelatedWork W1989083680 @default.
- W2063852893 hasRelatedWork W2023163531 @default.
- W2063852893 hasRelatedWork W2039659903 @default.
- W2063852893 hasRelatedWork W2066185644 @default.
- W2063852893 hasRelatedWork W2073938410 @default.
- W2063852893 hasRelatedWork W2082216829 @default.
- W2063852893 hasRelatedWork W2086293157 @default.
- W2063852893 hasRelatedWork W2099954099 @default.
- W2063852893 hasRelatedWork W2382280214 @default.
- W2063852893 hasRelatedWork W2950359189 @default.
- W2063852893 hasVolume "16" @default.
- W2063852893 isParatext "false" @default.
- W2063852893 isRetracted "false" @default.
- W2063852893 magId "2063852893" @default.
- W2063852893 workType "article" @default.