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• W2063855257 abstract "Novel pathogenic infectious retroviruses, generated by recombination between replication-defective endogenous retroviruses in the absence of a functional antibody response, are identified; these recombinant retroviruses establish infection of mouse colonies and ultimately cause cancer. Retroviruses can establish germline infections and become part of the host genome, but most of the resulting endogenous retroviruses, or ERVs, become inactive or transcriptionally silenced. This paper presents evidence for the emergence of novel pathogenic infectious retroviruses generated by recombination between replication-defective ERVs in the absence of a functional antibody response. The viruses are shown to be transmissible in mouse colonies, and to give rise to a range of pathologies, including cancer. Resurrection of ERVs in the context of antibody deficiency is less pronounced in the absence of a complex microbiota. This work reveals a previously unappreciated role for immunity in the control of ERVs. The mammalian host has developed a long-standing symbiotic relationship with a considerable number of microbial species. These include the microbiota on environmental surfaces, such as the respiratory and gastrointestinal tracts1, and also endogenous retroviruses (ERVs), comprising a substantial fraction of the mammalian genome2,3. The long-term consequences for the host of interactions with these microbial species can range from mutualism to parasitism and are not always completely understood. The potential effect of one microbial symbiont on another is even less clear. Here we study the control of ERVs in the commonly used C57BL/6 (B6) mouse strain, which lacks endogenous murine leukaemia viruses (MLVs) able to replicate in murine cells. We demonstrate the spontaneous emergence of fully infectious ecotropic4 MLV in B6 mice with a range of distinct immune deficiencies affecting antibody production. These recombinant retroviruses establish infection of immunodeficient mouse colonies, and ultimately result in retrovirus-induced lymphomas. Notably, ERV activation in immunodeficient mice is prevented in husbandry conditions associated with reduced or absent intestinal microbiota. Our results shed light onto a previously unappreciated role for immunity in the control of ERVs and provide a potential mechanistic link between immune activation by microbial triggers and a range of pathologies associated with ERVs, including cancer." @default.
• W2063855257 created "2016-06-24" @default.
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• W2063855257 date "2012-10-24" @default.
• W2063855257 modified "2023-10-15" @default.
• W2063855257 title "Resurrection of endogenous retroviruses in antibody-deficient mice" @default.
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• W2063855257 doi "https://doi.org/10.1038/nature11599" @default.
• W2063855257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3511586" @default.
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