FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063855596> ?p ?o ?g. }

• W2063855596 endingPage "204" @default.
• W2063855596 startingPage "195" @default.
• W2063855596 abstract "During lytic infections, the virion host shutoff (vhs) function of herpes simplex virus (HSV) disaggregates host polysomes and induces rapid turnover of both cellular and viral mRNAs. To examine the steps in vhs-induced mRNA degradation, an RNase protection assay was used to compare the relative decay rates of sequences from the 5' and 3' ends of a selected target mRNA. In cells infected with wild-type HSV-1, sequences at the 5' end of the HSV-1 thymidine kinase mRNA were degraded more rapidly than those at the 3' end of the transcript. In contrast, in cells infected with a vhs mutant, the decay rates of sequences at the 5' and 3' termini of the transcript were much slower and were essentially indistinguishable from each other. Vhs-induced degradation of the transcribed portion of the mRNA was not preceded by detectable shortening of the poly(A) tail in vivo; nor was a poly(A) tail required to make an RNA a target for the vhs activity in vitro. The results suggest that degradation of sequences at or near the 5' end of an mRNA is an early step in vhs-induced decay." @default.
• W2063855596 created "2016-06-24" @default.
• W2063855596 creator A5037202687 @default.
• W2063855596 creator A5070161199 @default.
• W2063855596 date "1999-11-01" @default.
• W2063855596 modified "2023-09-28" @default.
• W2063855596 title "The Virion Host Shutoff Function of Herpes Simplex Virus Degrades the 5′ End of a Target mRNA before the 3′ End" @default.
• W2063855596 cites W131472882 @default.
• W2063855596 cites W1509026992 @default.
• W2063855596 cites W1539798432 @default.
• W2063855596 cites W1548696821 @default.
• W2063855596 cites W1606830172 @default.
• W2063855596 cites W1607374780 @default.
• W2063855596 cites W1652175984 @default.
• W2063855596 cites W1710344093 @default.
• W2063855596 cites W1751490891 @default.
• W2063855596 cites W1824684517 @default.
• W2063855596 cites W1854770036 @default.
• W2063855596 cites W1863903014 @default.
• W2063855596 cites W1898229461 @default.
• W2063855596 cites W1938377731 @default.
• W2063855596 cites W1970403529 @default.
• W2063855596 cites W1978202804 @default.
• W2063855596 cites W1978809302 @default.
• W2063855596 cites W1995737813 @default.
• W2063855596 cites W1999964184 @default.
• W2063855596 cites W2001748566 @default.
• W2063855596 cites W2015654553 @default.
• W2063855596 cites W2023497052 @default.
• W2063855596 cites W2035270583 @default.
• W2063855596 cites W2042299243 @default.
• W2063855596 cites W2059633680 @default.
• W2063855596 cites W2082658854 @default.
• W2063855596 cites W2090441795 @default.
• W2063855596 cites W2104820327 @default.
• W2063855596 cites W2105568629 @default.
• W2063855596 cites W2107680679 @default.
• W2063855596 cites W2115761677 @default.
• W2063855596 cites W2125207784 @default.
• W2063855596 cites W2126204454 @default.
• W2063855596 cites W2129566110 @default.
• W2063855596 cites W2134910640 @default.
• W2063855596 cites W2147990979 @default.
• W2063855596 cites W2153973987 @default.
• W2063855596 cites W2161714250 @default.
• W2063855596 cites W217134834 @default.
• W2063855596 cites W2185097006 @default.
• W2063855596 cites W4229839001 @default.
• W2063855596 cites W4236610047 @default.
• W2063855596 cites W4256236320 @default.
• W2063855596 doi "https://doi.org/10.1006/viro.1999.9986" @default.
• W2063855596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10544145" @default.
• W2063855596 hasPublicationYear "1999" @default.
• W2063855596 type Work @default.
• W2063855596 sameAs 2063855596 @default.
• W2063855596 citedByCount "70" @default.
• W2063855596 countsByYear W20638555962013 @default.
• W2063855596 countsByYear W20638555962014 @default.
• W2063855596 countsByYear W20638555962015 @default.
• W2063855596 countsByYear W20638555962016 @default.
• W2063855596 countsByYear W20638555962018 @default.
• W2063855596 countsByYear W20638555962019 @default.
• W2063855596 countsByYear W20638555962020 @default.
• W2063855596 countsByYear W20638555962022 @default.
• W2063855596 countsByYear W20638555962023 @default.
• W2063855596 crossrefType "journal-article" @default.
• W2063855596 hasAuthorship W2063855596A5037202687 @default.
• W2063855596 hasAuthorship W2063855596A5070161199 @default.
• W2063855596 hasBestOaLocation W20638555961 @default.
• W2063855596 hasConcept C104317684 @default.
• W2063855596 hasConcept C105580179 @default.
• W2063855596 hasConcept C153911025 @default.
• W2063855596 hasConcept C159047783 @default.
• W2063855596 hasConcept C182615771 @default.
• W2063855596 hasConcept C2522874641 @default.
• W2063855596 hasConcept C2781196997 @default.
• W2063855596 hasConcept C55493867 @default.
• W2063855596 hasConcept C65666806 @default.
• W2063855596 hasConcept C67705224 @default.
• W2063855596 hasConcept C86803240 @default.
• W2063855596 hasConcept C88478588 @default.
• W2063855596 hasConcept C95444343 @default.
• W2063855596 hasConceptScore W2063855596C104317684 @default.
• W2063855596 hasConceptScore W2063855596C105580179 @default.
• W2063855596 hasConceptScore W2063855596C153911025 @default.
• W2063855596 hasConceptScore W2063855596C159047783 @default.
• W2063855596 hasConceptScore W2063855596C182615771 @default.
• W2063855596 hasConceptScore W2063855596C2522874641 @default.
• W2063855596 hasConceptScore W2063855596C2781196997 @default.
• W2063855596 hasConceptScore W2063855596C55493867 @default.
• W2063855596 hasConceptScore W2063855596C65666806 @default.
• W2063855596 hasConceptScore W2063855596C67705224 @default.
• W2063855596 hasConceptScore W2063855596C86803240 @default.
• W2063855596 hasConceptScore W2063855596C88478588 @default.
• W2063855596 hasConceptScore W2063855596C95444343 @default.
• W2063855596 hasIssue "1" @default.
• W2063855596 hasLocation W20638555961 @default.
• W2063855596 hasLocation W20638555962 @default.

• next