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- W2063862404 abstract "Biomarker discovery and validation is a central application in current proteomic research to improve the diagnosis, treatment monitoring and prognosis of many diseases, including cancer, and vascular, neurological and autoimmune disorders. Mass spectrometry (MS)-based proteomics is heralded to offer substantial advantages over traditional antibody-based clinical assays, namely greater specificity, cost–effectiveness, time–effectiveness and the potential to multiplex up to hundreds of peptides in a single assay. The clinical proteomics prof iling approach was initially defined as the direct application of proteomics technologies in combination with informatics tools to discover disease-associated changes in patterns of peptide profiles for direct diagnostic purpose [1]. However, it became increasingly evident that respective peaks within the peptidomics profiles needed to be identified [2]. Over the past few years, tremendous progress in MS instrumentation has been achieved that has fueled progress in the field. Modern proteomics methods comprise a plethora of heterogeneous techniques allowing not only protein and peptide patterns to be analyzed, but also biomarkers to be identified and quantified of. The MS-based biomarker discovery can be grouped into three main strategies:" @default.
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- W2063862404 date "2009-10-01" @default.
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- W2063862404 title "Mass spectrometry-based clinical proteomics profiling: current status and future directions" @default.
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- W2063862404 doi "https://doi.org/10.1586/epr.09.67" @default.
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