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• W2063862635 abstract "Factors determining the specificity of immunocytochemical (ICC) tissue stainings as well as the various tests to study these factors are discussed. Since every specificity test only deals with particular aspects of the ICC procedure, a practical sequence of known test methods is proposed, which enables the determination of the specificity of the ICC tissue staining and, after possibly needed antiserum purification steps, may result in a monospecific staining. It is made clear that such a sequence has always to include a tissue-spectrum affinity test, in which the spectrum of tissue antigens is controlled for antibody binding. A variety of such tests, consisting of separation of tissue compounds, fixation, and ICC detection, are discussed as well as their pros and cons with respect to their predictability for the actual serum specificity in the tissue section." @default.
• W2063862635 created "2016-06-24" @default.
• W2063862635 creator A5018414595 @default.
• W2063862635 creator A5084557920 @default.
• W2063862635 date "1986-01-01" @default.
• W2063862635 modified "2023-09-27" @default.
• W2063862635 title "The relevance of various tests for the study of specificity in immunocytochemical staining: A review" @default.
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• W2063862635 doi "https://doi.org/10.1002/cbf.290040102" @default.
• W2063862635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2417739" @default.
• W2063862635 hasPublicationYear "1986" @default.
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