FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063886117> ?p ?o ?g. }

• W2063886117 endingPage "3230" @default.
• W2063886117 startingPage "3227" @default.
• W2063886117 abstract "The presenilin proteins are involved in the proteolytic processing of transmembrane proteins such as Notch/lin-12 and the beta-amyloid precursor protein (betaAPP). Mutation of a conserved cysteine (Cys60Ser) in the C. elegans presenilin sel-12 has a loss-of-function effect on Notch/lin-12 processing similar to that of null mutations in sel-12. In contrast, in mammalian cells, most missense mutations increase gamma-secretase cleavage of betaAPP. We report here that mutation of this conserved cysteine (Cys92Ser) in human presenilin 1 confers a loss-of-function effect in C. elegans, but causes increased A beta42 secretion in mammalian cells. These data suggest that the role of presenilins in Notch/lin-12 signalling and betaAPP processing are either separately regulated activities or independent activities of the presenilins." @default.
• W2063886117 created "2016-06-24" @default.
• W2063886117 creator A5009546157 @default.
• W2063886117 creator A5012238780 @default.
• W2063886117 creator A5012349154 @default.
• W2063886117 creator A5012586710 @default.
• W2063886117 creator A5022486266 @default.
• W2063886117 creator A5042766163 @default.
• W2063886117 creator A5044342845 @default.
• W2063886117 creator A5045000339 @default.
• W2063886117 creator A5060029859 @default.
• W2063886117 creator A5072115423 @default.
• W2063886117 creator A5072171783 @default.
• W2063886117 creator A5076073241 @default.
• W2063886117 creator A5082848087 @default.
• W2063886117 creator A5082917295 @default.
• W2063886117 creator A5086851177 @default.
• W2063886117 creator A5089921221 @default.
• W2063886117 creator A5090606294 @default.
• W2063886117 date "2000-09-01" @default.
• W2063886117 modified "2023-10-18" @default.
• W2063886117 title "Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased Aβ42 secretion in mammalian cells but impaired Notch/lin-I2 signalling in C. elegans" @default.
• W2063886117 cites W1595935608 @default.
• W2063886117 cites W1655397332 @default.
• W2063886117 cites W1967027232 @default.
• W2063886117 cites W1972706019 @default.
• W2063886117 cites W2010684406 @default.
• W2063886117 doi "https://doi.org/10.1097/00001756-200009280-00035" @default.
• W2063886117 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11043553" @default.
• W2063886117 hasPublicationYear "2000" @default.
• W2063886117 type Work @default.
• W2063886117 sameAs 2063886117 @default.
• W2063886117 citedByCount "34" @default.
• W2063886117 countsByYear W20638861172013 @default.
• W2063886117 countsByYear W20638861172022 @default.
• W2063886117 countsByYear W20638861172023 @default.
• W2063886117 crossrefType "journal-article" @default.
• W2063886117 hasAuthorship W2063886117A5009546157 @default.
• W2063886117 hasAuthorship W2063886117A5012238780 @default.
• W2063886117 hasAuthorship W2063886117A5012349154 @default.
• W2063886117 hasAuthorship W2063886117A5012586710 @default.
• W2063886117 hasAuthorship W2063886117A5022486266 @default.
• W2063886117 hasAuthorship W2063886117A5042766163 @default.
• W2063886117 hasAuthorship W2063886117A5044342845 @default.
• W2063886117 hasAuthorship W2063886117A5045000339 @default.
• W2063886117 hasAuthorship W2063886117A5060029859 @default.
• W2063886117 hasAuthorship W2063886117A5072115423 @default.
• W2063886117 hasAuthorship W2063886117A5072171783 @default.
• W2063886117 hasAuthorship W2063886117A5076073241 @default.
• W2063886117 hasAuthorship W2063886117A5082848087 @default.
• W2063886117 hasAuthorship W2063886117A5082917295 @default.
• W2063886117 hasAuthorship W2063886117A5086851177 @default.
• W2063886117 hasAuthorship W2063886117A5089921221 @default.
• W2063886117 hasAuthorship W2063886117A5090606294 @default.
• W2063886117 hasConcept C104317684 @default.
• W2063886117 hasConcept C126322002 @default.
• W2063886117 hasConcept C161879069 @default.
• W2063886117 hasConcept C175344181 @default.
• W2063886117 hasConcept C181199279 @default.
• W2063886117 hasConcept C202769670 @default.
• W2063886117 hasConcept C2779134260 @default.
• W2063886117 hasConcept C2779201268 @default.
• W2063886117 hasConcept C49039625 @default.
• W2063886117 hasConcept C501734568 @default.
• W2063886117 hasConcept C502032728 @default.
• W2063886117 hasConcept C54355233 @default.
• W2063886117 hasConcept C55493867 @default.
• W2063886117 hasConcept C62478195 @default.
• W2063886117 hasConcept C71924100 @default.
• W2063886117 hasConcept C75563809 @default.
• W2063886117 hasConcept C86803240 @default.
• W2063886117 hasConcept C95444343 @default.
• W2063886117 hasConceptScore W2063886117C104317684 @default.
• W2063886117 hasConceptScore W2063886117C126322002 @default.
• W2063886117 hasConceptScore W2063886117C161879069 @default.
• W2063886117 hasConceptScore W2063886117C175344181 @default.
• W2063886117 hasConceptScore W2063886117C181199279 @default.
• W2063886117 hasConceptScore W2063886117C202769670 @default.
• W2063886117 hasConceptScore W2063886117C2779134260 @default.
• W2063886117 hasConceptScore W2063886117C2779201268 @default.
• W2063886117 hasConceptScore W2063886117C49039625 @default.
• W2063886117 hasConceptScore W2063886117C501734568 @default.
• W2063886117 hasConceptScore W2063886117C502032728 @default.
• W2063886117 hasConceptScore W2063886117C54355233 @default.
• W2063886117 hasConceptScore W2063886117C55493867 @default.
• W2063886117 hasConceptScore W2063886117C62478195 @default.
• W2063886117 hasConceptScore W2063886117C71924100 @default.
• W2063886117 hasConceptScore W2063886117C75563809 @default.
• W2063886117 hasConceptScore W2063886117C86803240 @default.
• W2063886117 hasConceptScore W2063886117C95444343 @default.
• W2063886117 hasIssue "14" @default.
• W2063886117 hasLocation W20638861171 @default.
• W2063886117 hasLocation W20638861172 @default.
• W2063886117 hasOpenAccess W2063886117 @default.
• W2063886117 hasPrimaryLocation W20638861171 @default.
• W2063886117 hasRelatedWork W1540449879 @default.
• W2063886117 hasRelatedWork W1655397332 @default.
• W2063886117 hasRelatedWork W1675105744 @default.

• next