FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063886266> ?p ?o ?g. }

• W2063886266 endingPage "5850" @default.
• W2063886266 startingPage "5845" @default.
• W2063886266 abstract "Phosphoinositide‐dependent kinase 1 (PDK1) is essential for T cell development but little is know about the stimuli that regulate PDK1 signaling in vivo. The thymus contains a heterogeneous mixture of cells at different stages of development making it difficult to use biochemical techniques to examine the activity of PDK1 pathways as thymocytes develop in situ. Herein, we use a single cell assay to quantify activation of the PDK1 target kinase ribosomal S6 kinase 1 (S6K1) in different murine thymocyte subsets immediately ex vivo. This technique allows an assessment of S6K1 activation as thymocytes respond to developmental stimuli in vivo. These studies reveal that only a small percentage of thymocytes show evidence for activation of PDK1 mediated signaling in situ. The thymic subpopulations that contain active PDK1/S6K1 are those known to be responding to signaling by the pre T cell receptor and the mature alpha/beta T cell antigen receptor (TCR). Moreover, loss of antigen receptor signaling in T cell progenitors that cannot rearrange their TCR beta locus prevents in vivo activation of S6K1. The present data identifying antigen receptor signaling as a key activator of PDK1 mediated signaling afford a molecular explanation for the important role of this molecule in T cells." @default.
• W2063886266 created "2016-06-24" @default.
• W2063886266 creator A5005030023 @default.
• W2063886266 creator A5019327627 @default.
• W2063886266 creator A5076316100 @default.
• W2063886266 date "2006-09-28" @default.
• W2063886266 modified "2023-10-13" @default.
• W2063886266 title "Antigen receptor regulation of phosphoinositide‐dependent kinase 1 pathways during thymocyte development" @default.
• W2063886266 cites W1567968151 @default.
• W2063886266 cites W1992393431 @default.
• W2063886266 cites W1995421851 @default.
• W2063886266 cites W1998104632 @default.
• W2063886266 cites W2011282245 @default.
• W2063886266 cites W2017394099 @default.
• W2063886266 cites W2020823132 @default.
• W2063886266 cites W2028735719 @default.
• W2063886266 cites W2028749270 @default.
• W2063886266 cites W2030606525 @default.
• W2063886266 cites W2034980526 @default.
• W2063886266 cites W2041926656 @default.
• W2063886266 cites W2048943247 @default.
• W2063886266 cites W2053168337 @default.
• W2063886266 cites W2053894639 @default.
• W2063886266 cites W2059312466 @default.
• W2063886266 cites W2062356998 @default.
• W2063886266 cites W2067143990 @default.
• W2063886266 cites W2079123009 @default.
• W2063886266 cites W2086132113 @default.
• W2063886266 cites W2091572909 @default.
• W2063886266 cites W2094941511 @default.
• W2063886266 cites W2107912726 @default.
• W2063886266 cites W2114569569 @default.
• W2063886266 cites W2126464081 @default.
• W2063886266 cites W2135554082 @default.
• W2063886266 cites W2137764426 @default.
• W2063886266 cites W2140489687 @default.
• W2063886266 cites W2144437446 @default.
• W2063886266 cites W2157853291 @default.
• W2063886266 cites W2159990074 @default.
• W2063886266 cites W2166318113 @default.
• W2063886266 cites W2171815674 @default.
• W2063886266 cites W258316223 @default.
• W2063886266 cites W4234842415 @default.
• W2063886266 cites W4313422313 @default.
• W2063886266 doi "https://doi.org/10.1016/j.febslet.2006.09.045" @default.
• W2063886266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17027005" @default.
• W2063886266 hasPublicationYear "2006" @default.
• W2063886266 type Work @default.
• W2063886266 sameAs 2063886266 @default.
• W2063886266 citedByCount "11" @default.
• W2063886266 countsByYear W20638862662014 @default.
• W2063886266 countsByYear W20638862662016 @default.
• W2063886266 countsByYear W20638862662017 @default.
• W2063886266 countsByYear W20638862662022 @default.
• W2063886266 crossrefType "journal-article" @default.
• W2063886266 hasAuthorship W2063886266A5005030023 @default.
• W2063886266 hasAuthorship W2063886266A5019327627 @default.
• W2063886266 hasAuthorship W2063886266A5076316100 @default.
• W2063886266 hasConcept C104202773 @default.
• W2063886266 hasConcept C170493617 @default.
• W2063886266 hasConcept C19317047 @default.
• W2063886266 hasConcept C203014093 @default.
• W2063886266 hasConcept C2776090121 @default.
• W2063886266 hasConcept C2778954852 @default.
• W2063886266 hasConcept C55493867 @default.
• W2063886266 hasConcept C62478195 @default.
• W2063886266 hasConcept C86554907 @default.
• W2063886266 hasConcept C86803240 @default.
• W2063886266 hasConcept C8891405 @default.
• W2063886266 hasConcept C95444343 @default.
• W2063886266 hasConceptScore W2063886266C104202773 @default.
• W2063886266 hasConceptScore W2063886266C170493617 @default.
• W2063886266 hasConceptScore W2063886266C19317047 @default.
• W2063886266 hasConceptScore W2063886266C203014093 @default.
• W2063886266 hasConceptScore W2063886266C2776090121 @default.
• W2063886266 hasConceptScore W2063886266C2778954852 @default.
• W2063886266 hasConceptScore W2063886266C55493867 @default.
• W2063886266 hasConceptScore W2063886266C62478195 @default.
• W2063886266 hasConceptScore W2063886266C86554907 @default.
• W2063886266 hasConceptScore W2063886266C86803240 @default.
• W2063886266 hasConceptScore W2063886266C8891405 @default.
• W2063886266 hasConceptScore W2063886266C95444343 @default.
• W2063886266 hasIssue "25" @default.
• W2063886266 hasLocation W20638862661 @default.
• W2063886266 hasLocation W20638862662 @default.
• W2063886266 hasOpenAccess W2063886266 @default.
• W2063886266 hasPrimaryLocation W20638862661 @default.
• W2063886266 hasRelatedWork W1578407835 @default.
• W2063886266 hasRelatedWork W1848422231 @default.
• W2063886266 hasRelatedWork W2012972418 @default.
• W2063886266 hasRelatedWork W2026444950 @default.
• W2063886266 hasRelatedWork W2040128205 @default.
• W2063886266 hasRelatedWork W2056530167 @default.
• W2063886266 hasRelatedWork W2060075608 @default.
• W2063886266 hasRelatedWork W2094278677 @default.
• W2063886266 hasRelatedWork W2134595680 @default.
• W2063886266 hasRelatedWork W2168929838 @default.
• W2063886266 hasVolume "580" @default.

• next