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- W2063895799 abstract "Rainbow trout (Oncorhynchus mykiss) were exposed to various degrees of oxygen saturation (3.3–21.1 mg O2/l). After 5 h of exposure, trout were killed and DNA single-strand breaks (DSSB) were determind in the gills by the alkaline unwinding method. Significant increases of DSSB compared to normoxic conditions (11 mg O2/l) were observed under hypoxic and particularly hyperoxic conditions. The highest rate of DSSB occurred when the fish were kept under hypoxic conditions followed by a rapid increase of the oxygen concentration. DSSB formation under these conditions was comparable to that achieved by treatment with 200 μM of the potent carcinogen N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). These data demonstrate that natural influences, such as varying oxygen concentrations in the water, can be responsible for the induction of DSSB. These findings call into question the usefulness of the measurement of DSSB in fish as an indicator of water pollution by genotoxic chemicals." @default.
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- W2063895799 date "1995-09-01" @default.
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- W2063895799 title "Induction of DNA strand breaks in rainbow trout Oncorhynchus mykiss under hypoxic and hyperoxic conditions" @default.
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- W2063895799 doi "https://doi.org/10.1016/0166-445x(95)00016-w" @default.
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