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• W2063896182 abstract "Significance Understanding of the mechanisms of modulation of voltage-gated Na + (Na V ) channels by general anesthetic agents such as sevoflurane is critical to interpret their role in general anesthesia. By using the bacterial Na V channel analogue NaChBac plus a combination of computational and electrophysiological analyses, this work strongly suggests a multisite mechanism of sevoflurane action on Na V channels. Furthermore, computer simulations suggest specific putative anesthetic sites worthy of further investigation." @default.
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• W2063896182 date "2014-04-21" @default.
• W2063896182 modified "2023-10-14" @default.
• W2063896182 title "Modulation of a voltage-gated Na ⁺ channel by sevoflurane involves multiple sites and distinct mechanisms" @default.
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• W2063896182 doi "https://doi.org/10.1073/pnas.1405768111" @default.
• W2063896182 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4020080" @default.
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