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• W2063896244 abstract "For facilitated genotypic analysis of multiple endocrine neoplasia type 1 (MEN1), a familial syndrome associated with tumors of the parathyroid and neuroendocrine tissues, we developed two screening methods, heteroduplex mutation assay (HMA) and mutation detection gel analysis (MDGA), both based on electrophoretic discrimination of polymerase chain reaction (PCR) products, to detect the mutations. Forty-three genomic DNA samples were used for the evaluation of these techniques. The whole coding region of MEN1 was PCR-amplified with fluorescent primers and then denatured/renatured before electrophoresis on an automated sequencer. 100% of the mutations were detected, subsequently confirmed and identified by sequencing. Negative samples were used to evaluate the specificity and reproducibility of the two techniques. The combination of the two methods allows high throughput cost-effective mutation screening which is less laborious than systematic sequencing of the whole coding region of MEN1. Together, these methods provide an efficient screen for MEN1 mutations." @default.
• W2063896244 created "2016-06-24" @default.
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• W2063896244 date "2003-01-01" @default.
• W2063896244 modified "2023-10-16" @default.
• W2063896244 title "Efficient mutation detection in MEN1 gene using a combination of single-strand conformation polymorphism (MDGA™) and heteroduplex analysis" @default.
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• W2063896244 doi "https://doi.org/10.1002/elps.200390023" @default.
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