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• W2063911875 abstract "RNApolII-dependent transcription is repressed in primordial germ cells of many animals during early development and is thought to be important for maintenance of germline fate by preventing somatic differentiation [1Pirrotta V. Silence in the germ.Cell. 2002; 110: 661-664Abstract Full Text Full Text PDF PubMed Scopus (21) Google Scholar]. Germ cell transcriptional repression occurs concurrently with inhibition of phosphorylation in the carboxy-terminal domain (CTD) of RNApolII, as well as with chromatin remodeling [2Seydoux G. Dunn M.A. Transcriptionally repressed germ cells lack a subpopulation of phosphorylated RNA polymerase II in early embryos of Caenorhabditis elegans and Drosophila melanogaster.Development. 1997; 124: 2191-2202PubMed Google Scholar, 3Unhavaithaya Y. Shin T.H. Miliaras N. Lee J. Oyama T. Mello C.C. MEP-1 and a homolog of the NURD complex component Mi-2 act together to maintain germline-soma distinctions in C. elegans.Cell. 2002; 111: 991-1002Abstract Full Text Full Text PDF PubMed Scopus (148) Google Scholar, 4Batchelder C. Dunn M.A. Choy B. Suh Y. Cassie C. Shim E.Y. Shin T.H. Mello C. Seydoux G. Blackwell T.K. Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1.Genes Dev. 1999; 13: 202-212Crossref PubMed Scopus (91) Google Scholar]. The precise mechanisms involved are unknown. Here, we present evidence that a noncoding RNA transcribed by the gene polar granule component (pgc) [5Nakamura A. Amikura R. Mukai M. Kobayashi S. Lasko P. Requirement for a noncoding RNA in Drosophila polar granules for germ cell establishment.Science. 1996; 274: 2075-2079Crossref PubMed Scopus (156) Google Scholar] regulates transcriptional repression in Drosophila germ cells. Germ cells lacking pgc RNA express genes important for differentiation of nearby somatic cells and show premature phosphorylation of RNApolII. We further show that germ cells lacking pgc show increased levels of K4, but not K9 histone H3 methylation, and that the chromatin remodeling Swi/Snf complex is required for a second stage in germ cell transcriptional repression. We propose that a noncoding RNA controls transcription in early germ cells by blocking the transition from preinitiation to transcriptional elongation. We further show that repression of somatic differentiation signals mediated by the Torso receptor-tyrosine kinase [6Furriols M. Casanova J. In and out of Torso RTK signalling.EMBO J. 2003; 22: 1947-1952Crossref PubMed Scopus (71) Google Scholar] is important for germline development." @default.
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• W2063911875 date "2004-01-01" @default.
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• W2063911875 title "A Noncoding RNA Is Required for the Repression of RNApolII-Dependent Transcription in Primordial Germ Cells" @default.
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• W2063911875 doi "https://doi.org/10.1016/j.cub.2003.12.036" @default.
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