FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063917811> ?p ?o ?g. }

• W2063917811 endingPage "486" @default.
• W2063917811 startingPage "481" @default.
• W2063917811 abstract "Cellular expression of the TP53-induced glycolysis and apoptosis regulator (TIGAR) protein results in the down-regulation of glycolysis, reduction of intracellular levels of reactive oxygen species, and protection from apoptosis. However, despite its biological importance, the mechanisms that regulate its expression remain obscure. The bioinformatic analysis performed in this study indicates that the TIGAR promoter region is highly conserved among species. Further analysis using 5'-deletion analysis and site-directed mutagenesis demonstrated that the region at -4/+13 contained a cAMP-response element (CRE). EMSA and chromatin immunoprecipitation showed that the site was recognized by CRE-binding protein (CREB). Furthermore, knockdown of CREB substantially reduced promoter activity and TIGAR expression in cells. In addition, over-expression of either CREB or forskolin enhanced promoter activity and TIGAR expression. These results provide evidence that CREB regulates TIGAR expression via a CRE-binding site at the TIGAR promoter." @default.
• W2063917811 created "2016-06-24" @default.
• W2063917811 creator A5009318195 @default.
• W2063917811 creator A5010381174 @default.
• W2063917811 creator A5014188911 @default.
• W2063917811 creator A5021109334 @default.
• W2063917811 creator A5021252332 @default.
• W2063917811 creator A5030594393 @default.
• W2063917811 creator A5032473290 @default.
• W2063917811 creator A5090895269 @default.
• W2063917811 date "2013-10-01" @default.
• W2063917811 modified "2023-09-25" @default.
• W2063917811 title "CREB, another culprit for TIGAR promoter activity and expression" @default.
• W2063917811 cites W1545443160 @default.
• W2063917811 cites W1980443827 @default.
• W2063917811 cites W1988004907 @default.
• W2063917811 cites W1988048122 @default.
• W2063917811 cites W2000253969 @default.
• W2063917811 cites W2013747211 @default.
• W2063917811 cites W2016406801 @default.
• W2063917811 cites W2030992905 @default.
• W2063917811 cites W2033529039 @default.
• W2063917811 cites W2034861130 @default.
• W2063917811 cites W2071846153 @default.
• W2063917811 cites W2084085176 @default.
• W2063917811 cites W2086204970 @default.
• W2063917811 cites W2088359631 @default.
• W2063917811 cites W2097259163 @default.
• W2063917811 cites W2117921553 @default.
• W2063917811 cites W2119239003 @default.
• W2063917811 cites W2124432707 @default.
• W2063917811 cites W2137385309 @default.
• W2063917811 cites W2159006160 @default.
• W2063917811 cites W2160295920 @default.
• W2063917811 cites W2163981813 @default.
• W2063917811 doi "https://doi.org/10.1016/j.bbrc.2013.08.098" @default.
• W2063917811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24036271" @default.
• W2063917811 hasPublicationYear "2013" @default.
• W2063917811 type Work @default.
• W2063917811 sameAs 2063917811 @default.
• W2063917811 citedByCount "14" @default.
• W2063917811 countsByYear W20639178112014 @default.
• W2063917811 countsByYear W20639178112015 @default.
• W2063917811 countsByYear W20639178112018 @default.
• W2063917811 countsByYear W20639178112019 @default.
• W2063917811 countsByYear W20639178112020 @default.
• W2063917811 countsByYear W20639178112021 @default.
• W2063917811 countsByYear W20639178112022 @default.
• W2063917811 countsByYear W20639178112023 @default.
• W2063917811 crossrefType "journal-article" @default.
• W2063917811 hasAuthorship W2063917811A5009318195 @default.
• W2063917811 hasAuthorship W2063917811A5010381174 @default.
• W2063917811 hasAuthorship W2063917811A5014188911 @default.
• W2063917811 hasAuthorship W2063917811A5021109334 @default.
• W2063917811 hasAuthorship W2063917811A5021252332 @default.
• W2063917811 hasAuthorship W2063917811A5030594393 @default.
• W2063917811 hasAuthorship W2063917811A5032473290 @default.
• W2063917811 hasAuthorship W2063917811A5090895269 @default.
• W2063917811 hasConcept C101762097 @default.
• W2063917811 hasConcept C104317684 @default.
• W2063917811 hasConcept C132376346 @default.
• W2063917811 hasConcept C134320426 @default.
• W2063917811 hasConcept C150194340 @default.
• W2063917811 hasConcept C153911025 @default.
• W2063917811 hasConcept C1629964 @default.
• W2063917811 hasConcept C165864922 @default.
• W2063917811 hasConcept C173396325 @default.
• W2063917811 hasConcept C190283241 @default.
• W2063917811 hasConcept C27153228 @default.
• W2063917811 hasConcept C54355233 @default.
• W2063917811 hasConcept C86339819 @default.
• W2063917811 hasConcept C86803240 @default.
• W2063917811 hasConcept C95444343 @default.
• W2063917811 hasConceptScore W2063917811C101762097 @default.
• W2063917811 hasConceptScore W2063917811C104317684 @default.
• W2063917811 hasConceptScore W2063917811C132376346 @default.
• W2063917811 hasConceptScore W2063917811C134320426 @default.
• W2063917811 hasConceptScore W2063917811C150194340 @default.
• W2063917811 hasConceptScore W2063917811C153911025 @default.
• W2063917811 hasConceptScore W2063917811C1629964 @default.
• W2063917811 hasConceptScore W2063917811C165864922 @default.
• W2063917811 hasConceptScore W2063917811C173396325 @default.
• W2063917811 hasConceptScore W2063917811C190283241 @default.
• W2063917811 hasConceptScore W2063917811C27153228 @default.
• W2063917811 hasConceptScore W2063917811C54355233 @default.
• W2063917811 hasConceptScore W2063917811C86339819 @default.
• W2063917811 hasConceptScore W2063917811C86803240 @default.
• W2063917811 hasConceptScore W2063917811C95444343 @default.
• W2063917811 hasIssue "4" @default.
• W2063917811 hasLocation W20639178111 @default.
• W2063917811 hasLocation W20639178112 @default.
• W2063917811 hasOpenAccess W2063917811 @default.
• W2063917811 hasPrimaryLocation W20639178111 @default.
• W2063917811 hasRelatedWork W1985189742 @default.
• W2063917811 hasRelatedWork W2013433656 @default.
• W2063917811 hasRelatedWork W2050066548 @default.
• W2063917811 hasRelatedWork W2145132507 @default.
• W2063917811 hasRelatedWork W2188755994 @default.

• next