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- W2063918851 abstract "Arkadia (also known as RING finger 111) encodes a nuclear E3 ubiquitin ligase that targets intracellular effectors and modulators of TGFβ/Nodal-related signaling for polyubiquitination and proteasome-dependent degradation. In the mouse, loss of Arkadia results in early embryonic lethality, with defects attributed to compromised Nodal signaling. Here, we report the isolation of zebrafish arkadia/rnf111, which is represented by 5 transcript variants. arkadia/rnf111 is broadly expressed during the blastula and gastrula stages, with eventual enrichment in the anterior mesendoderm, including the prechordal plate. Morpholino knockdown experiments reveal an unexpected role for Arkadia/Rnf111 in both early blastula organization and epiboly progression. Using a splice junction morpholino, we present additional evidence that arkadia/rnf111 transcript variants containing a 3′ alternative exon are specifically required for epiboly progression in the late gastrula. This result suggests that arkadia/rnf111 transcript variants encode functionally relevant protein isoforms that provide additional intracellular flexibility and regulation to the Nodal signaling pathway." @default.
- W2063918851 created "2016-06-24" @default.
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- W2063918851 date "2015-01-01" @default.
- W2063918851 modified "2023-09-23" @default.
- W2063918851 title "Zebrafish Rnf111 is encoded by multiple transcripts and is required for epiboly progression and prechordal plate development" @default.
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- W2063918851 doi "https://doi.org/10.1016/j.diff.2014.12.004" @default.
- W2063918851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25619648" @default.
- W2063918851 hasPublicationYear "2015" @default.
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