Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063938627> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2063938627 endingPage "269" @default.
- W2063938627 startingPage "261" @default.
- W2063938627 abstract "Thioguanine, a chemotherapeutic drug employed in the treatment of leukemia, was encapsulated in three kinds of liposomes: extrusion, ethanol injection and dehydration-rehydration vesicles. The degree of entrapment was examined at three different concentrations, 1, 0.1 and 0.01 mM, and three pH values, 4.7, 7.4 and 9.2. Thioguanine had a considerable ability to cross the lipid bilayer, especially if the molecule presented a net charge. Like the amphiphilic drugs it was very permeant. Concerning the kind of liposomes, dehydration-rehydration of vesicles was found to be the optimal method for encapsulation of thioguanine irrespective of the pH. At pH 4.7 an encapsulation efficiency of 12 mmol/mol of lipid was elicited. The other methods never entrapped more than 3 mmol/mol of lipid. This behaviour can be explained by the formation in the drug of intermolecular bonds by hydrogen bridges during the process of lyophilization. The product formed might encounter greater difficulty in escaping from the vesicle than the non-bonded thioguanine. On the other hand, pH 4.7 also afforded more efficient encapsulation than the other pH values. Furthermore, this pH corresponds to the maximal apparent partition coefficient, and, consequently, to the maximal neutrality of the molecule. At this point, thioguanine is present as a neutral or as zwitterionic species. From these findings it can be inferred that entrapped thioguanine, as a zwitterionic form, is associated with the membrane lipids by means of electrostatic interactions with the zwitterionic phospholipid." @default.
- W2063938627 created "2016-06-24" @default.
- W2063938627 creator A5002473183 @default.
- W2063938627 creator A5010107361 @default.
- W2063938627 date "1995-10-01" @default.
- W2063938627 modified "2023-09-23" @default.
- W2063938627 title "Encapsulation of thioguanine in liposomes" @default.
- W2063938627 cites W140561389 @default.
- W2063938627 cites W1970502718 @default.
- W2063938627 cites W1978029175 @default.
- W2063938627 cites W2003399028 @default.
- W2063938627 cites W2005324582 @default.
- W2063938627 cites W2012196034 @default.
- W2063938627 cites W2013009465 @default.
- W2063938627 cites W2032987177 @default.
- W2063938627 cites W2053982909 @default.
- W2063938627 cites W2060292764 @default.
- W2063938627 cites W2069520354 @default.
- W2063938627 doi "https://doi.org/10.1016/0378-5173(95)00097-3" @default.
- W2063938627 hasPublicationYear "1995" @default.
- W2063938627 type Work @default.
- W2063938627 sameAs 2063938627 @default.
- W2063938627 citedByCount "17" @default.
- W2063938627 countsByYear W20639386272013 @default.
- W2063938627 countsByYear W20639386272015 @default.
- W2063938627 countsByYear W20639386272017 @default.
- W2063938627 countsByYear W20639386272018 @default.
- W2063938627 countsByYear W20639386272020 @default.
- W2063938627 countsByYear W20639386272021 @default.
- W2063938627 crossrefType "journal-article" @default.
- W2063938627 hasAuthorship W2063938627A5002473183 @default.
- W2063938627 hasAuthorship W2063938627A5010107361 @default.
- W2063938627 hasConcept C112887158 @default.
- W2063938627 hasConcept C12554922 @default.
- W2063938627 hasConcept C130316041 @default.
- W2063938627 hasConcept C15920480 @default.
- W2063938627 hasConcept C178790620 @default.
- W2063938627 hasConcept C185154212 @default.
- W2063938627 hasConcept C185592680 @default.
- W2063938627 hasConcept C192157962 @default.
- W2063938627 hasConcept C192552737 @default.
- W2063938627 hasConcept C2778769901 @default.
- W2063938627 hasConcept C2778918659 @default.
- W2063938627 hasConcept C32909587 @default.
- W2063938627 hasConcept C39944091 @default.
- W2063938627 hasConcept C41625074 @default.
- W2063938627 hasConcept C43617362 @default.
- W2063938627 hasConcept C521977710 @default.
- W2063938627 hasConcept C55493867 @default.
- W2063938627 hasConcept C67407626 @default.
- W2063938627 hasConcept C77281830 @default.
- W2063938627 hasConcept C86803240 @default.
- W2063938627 hasConceptScore W2063938627C112887158 @default.
- W2063938627 hasConceptScore W2063938627C12554922 @default.
- W2063938627 hasConceptScore W2063938627C130316041 @default.
- W2063938627 hasConceptScore W2063938627C15920480 @default.
- W2063938627 hasConceptScore W2063938627C178790620 @default.
- W2063938627 hasConceptScore W2063938627C185154212 @default.
- W2063938627 hasConceptScore W2063938627C185592680 @default.
- W2063938627 hasConceptScore W2063938627C192157962 @default.
- W2063938627 hasConceptScore W2063938627C192552737 @default.
- W2063938627 hasConceptScore W2063938627C2778769901 @default.
- W2063938627 hasConceptScore W2063938627C2778918659 @default.
- W2063938627 hasConceptScore W2063938627C32909587 @default.
- W2063938627 hasConceptScore W2063938627C39944091 @default.
- W2063938627 hasConceptScore W2063938627C41625074 @default.
- W2063938627 hasConceptScore W2063938627C43617362 @default.
- W2063938627 hasConceptScore W2063938627C521977710 @default.
- W2063938627 hasConceptScore W2063938627C55493867 @default.
- W2063938627 hasConceptScore W2063938627C67407626 @default.
- W2063938627 hasConceptScore W2063938627C77281830 @default.
- W2063938627 hasConceptScore W2063938627C86803240 @default.
- W2063938627 hasIssue "2" @default.
- W2063938627 hasLocation W20639386271 @default.
- W2063938627 hasOpenAccess W2063938627 @default.
- W2063938627 hasPrimaryLocation W20639386271 @default.
- W2063938627 hasRelatedWork W1989589392 @default.
- W2063938627 hasRelatedWork W1992349382 @default.
- W2063938627 hasRelatedWork W2062717317 @default.
- W2063938627 hasRelatedWork W2089532729 @default.
- W2063938627 hasRelatedWork W2117981102 @default.
- W2063938627 hasRelatedWork W2122118872 @default.
- W2063938627 hasRelatedWork W2133772902 @default.
- W2063938627 hasRelatedWork W2594002376 @default.
- W2063938627 hasRelatedWork W4229445260 @default.
- W2063938627 hasRelatedWork W4383896734 @default.
- W2063938627 hasVolume "124" @default.
- W2063938627 isParatext "false" @default.
- W2063938627 isRetracted "false" @default.
- W2063938627 magId "2063938627" @default.
- W2063938627 workType "article" @default.