FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063965996> ?p ?o ?g. }

• W2063965996 endingPage "e48720" @default.
• W2063965996 startingPage "e48720" @default.
• W2063965996 abstract "In Drosophila, the pattern of adult pigmentation is initiated during late pupal stages by the production of catecholamines DOPA and dopamine, which are converted to melanin. The pattern and degree of melanin deposition is controlled by the expression of genes such as ebony and yellow as well as by the enzymes involved in catecholamine biosynthesis. In this study, we show that the conserved TSC/TORC1 cell growth pathway controls catecholamine biosynthesis in Drosophila during pigmentation. We find that high levels of Rheb, an activator of the TORC1 complex, promote premature pigmentation in the mechanosensory bristles during pupal stages, and alter pigmentation in the cuticle of the adult fly. Disrupting either melanin synthesis by RNAi knockdown of melanogenic enzymes such as tyrosine hydroxylase (TH), or downregulating TORC1 activity by Raptor knockdown, suppresses the Rheb-dependent pigmentation phenotype in vivo. Increased Rheb activity drives pigmentation by increasing levels of TH in epidermal cells. Our findings indicate that control of pigmentation is linked to the cellular nutrient-sensing pathway by regulating levels of a critical enzyme in melanogenesis, providing further evidence that inappropriate activation of TORC1, a hallmark of the human tuberous sclerosis complex tumor syndrome disorder, can alter metabolic and differentiation pathways in unexpected ways." @default.
• W2063965996 created "2016-06-24" @default.
• W2063965996 creator A5033741473 @default.
• W2063965996 creator A5051979437 @default.
• W2063965996 creator A5054165528 @default.
• W2063965996 creator A5073560542 @default.
• W2063965996 creator A5086746753 @default.
• W2063965996 date "2012-11-07" @default.
• W2063965996 modified "2023-10-16" @default.
• W2063965996 title "The TSC1/2 Complex Controls Drosophila Pigmentation through TORC1-Dependent Regulation of Catecholamine Biosynthesis" @default.
• W2063965996 cites W1970111367 @default.
• W2063965996 cites W2001443196 @default.
• W2063965996 cites W2002226709 @default.
• W2063965996 cites W2002327194 @default.
• W2063965996 cites W2006229889 @default.
• W2063965996 cites W2006559495 @default.
• W2063965996 cites W2032685334 @default.
• W2063965996 cites W2043092063 @default.
• W2063965996 cites W2048974937 @default.
• W2063965996 cites W2067918274 @default.
• W2063965996 cites W2077044475 @default.
• W2063965996 cites W2082853003 @default.
• W2063965996 cites W2085392189 @default.
• W2063965996 cites W2086079901 @default.
• W2063965996 cites W2096131346 @default.
• W2063965996 cites W2104855680 @default.
• W2063965996 cites W2110643873 @default.
• W2063965996 cites W2112616760 @default.
• W2063965996 cites W2155111434 @default.
• W2063965996 cites W2162249333 @default.
• W2063965996 doi "https://doi.org/10.1371/journal.pone.0048720" @default.
• W2063965996 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3492411" @default.
• W2063965996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23144943" @default.
• W2063965996 hasPublicationYear "2012" @default.
• W2063965996 type Work @default.
• W2063965996 sameAs 2063965996 @default.
• W2063965996 citedByCount "10" @default.
• W2063965996 countsByYear W20639659962012 @default.
• W2063965996 countsByYear W20639659962013 @default.
• W2063965996 countsByYear W20639659962015 @default.
• W2063965996 countsByYear W20639659962016 @default.
• W2063965996 countsByYear W20639659962017 @default.
• W2063965996 countsByYear W20639659962019 @default.
• W2063965996 countsByYear W20639659962021 @default.
• W2063965996 countsByYear W20639659962022 @default.
• W2063965996 crossrefType "journal-article" @default.
• W2063965996 hasAuthorship W2063965996A5033741473 @default.
• W2063965996 hasAuthorship W2063965996A5051979437 @default.
• W2063965996 hasAuthorship W2063965996A5054165528 @default.
• W2063965996 hasAuthorship W2063965996A5073560542 @default.
• W2063965996 hasAuthorship W2063965996A5086746753 @default.
• W2063965996 hasBestOaLocation W20639659961 @default.
• W2063965996 hasConcept C104317684 @default.
• W2063965996 hasConcept C107538193 @default.
• W2063965996 hasConcept C134018914 @default.
• W2063965996 hasConcept C159167319 @default.
• W2063965996 hasConcept C173396325 @default.
• W2063965996 hasConcept C181199279 @default.
• W2063965996 hasConcept C2775894120 @default.
• W2063965996 hasConcept C2776773979 @default.
• W2063965996 hasConcept C2778937405 @default.
• W2063965996 hasConcept C2909523446 @default.
• W2063965996 hasConcept C513476851 @default.
• W2063965996 hasConcept C55493867 @default.
• W2063965996 hasConcept C62478195 @default.
• W2063965996 hasConcept C86554907 @default.
• W2063965996 hasConcept C86803240 @default.
• W2063965996 hasConcept C87554066 @default.
• W2063965996 hasConcept C95444343 @default.
• W2063965996 hasConcept C98335778 @default.
• W2063965996 hasConcept C98490376 @default.
• W2063965996 hasConceptScore W2063965996C104317684 @default.
• W2063965996 hasConceptScore W2063965996C107538193 @default.
• W2063965996 hasConceptScore W2063965996C134018914 @default.
• W2063965996 hasConceptScore W2063965996C159167319 @default.
• W2063965996 hasConceptScore W2063965996C173396325 @default.
• W2063965996 hasConceptScore W2063965996C181199279 @default.
• W2063965996 hasConceptScore W2063965996C2775894120 @default.
• W2063965996 hasConceptScore W2063965996C2776773979 @default.
• W2063965996 hasConceptScore W2063965996C2778937405 @default.
• W2063965996 hasConceptScore W2063965996C2909523446 @default.
• W2063965996 hasConceptScore W2063965996C513476851 @default.
• W2063965996 hasConceptScore W2063965996C55493867 @default.
• W2063965996 hasConceptScore W2063965996C62478195 @default.
• W2063965996 hasConceptScore W2063965996C86554907 @default.
• W2063965996 hasConceptScore W2063965996C86803240 @default.
• W2063965996 hasConceptScore W2063965996C87554066 @default.
• W2063965996 hasConceptScore W2063965996C95444343 @default.
• W2063965996 hasConceptScore W2063965996C98335778 @default.
• W2063965996 hasConceptScore W2063965996C98490376 @default.
• W2063965996 hasIssue "11" @default.
• W2063965996 hasLocation W20639659961 @default.
• W2063965996 hasLocation W20639659962 @default.
• W2063965996 hasLocation W20639659963 @default.
• W2063965996 hasLocation W20639659964 @default.
• W2063965996 hasLocation W20639659965 @default.
• W2063965996 hasOpenAccess W2063965996 @default.
• W2063965996 hasPrimaryLocation W20639659961 @default.

• next