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- W2063969884 abstract "Paraoxon (Px), an irreversible cholinesterase (ChE) inhibitor, was administered acutely and chronically to rats in order to elucidate the mechanisms involved in the process of adaptation. Brain levels of acetylcholine (ACh) as well as ChE and cholineacetyltransferase (CAT) activities were investigated to further understand the relationship between chronically reduced ChE levels and neurotransmitter mobilization. In acutely treated animals, cholinergic symptoms were evident 15 min after injection and were accompanied by a 100 per cent increase in total brain ACh and an 83 per cent decrease in ChE activity. In low-dose chronically treated animals, symptoms did not ensue until 3 days of treatment, when total ACh levels reached a maximum of 50 per cent above control and ChE activity was 55 per cent inhibited. Free ACh levels increased in both acutely and chronically treated animals, whereas bound ACh levels increased significantly only in the acutely treated group. These results suggest that (1) cholinergic central nervous system symptoms can be correlated to an increase (50 per cent) in brain ACh, and (2) chronic ChE inhibition may lead to alterations in the pre-synaptic mobilization and storage of ACh." @default.
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- W2063969884 date "1977-04-01" @default.
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- W2063969884 title "Central cholinergic mechanisms underlying adaptation to reduced cholinesterase activity" @default.
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- W2063969884 doi "https://doi.org/10.1016/0006-2952(77)90037-5" @default.
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