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• W2063973368 abstract "Jun dimerization protein 2 (JDP2) is a repressor of transcription factor AP-1. To investigate the transcriptional regulation of the JDP2 gene, we cloned the 5′-flanking region of the mouse JDP2 gene. Primer extension analysis revealed a new transcription start site (+1). Promoter analysis showed that the region from nt −343 to nt +177 contains basal transcriptional activity. Interestingly, the tumor suppressor p53 significantly repressed the transcriptional activity of the JDP2 promoter. Given that JDP2 inhibits expression of p53, our results suggest a negative feedback loop between JDP2 and p53, and a direct link between JDP2 and a key oncogenic pathway." @default.
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• W2063973368 date "2014-08-01" @default.
• W2063973368 modified "2023-10-17" @default.
• W2063973368 title "Cloning and characterization of the mouse JDP2 gene promoter reveal negative regulation by p53" @default.
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• W2063973368 doi "https://doi.org/10.1016/j.bbrc.2014.07.034" @default.
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