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- W2063974379 abstract "Abstract The effect of cadmium (5 μ/ml) on the growth of Euglena gracilis is moderated by the addition of supplemental zinc levels above the normal 1 μ/ml level found in the growth medium. Gel chromatography reveals that th majority (ca. 85%) of cytosolic cadmium is localized in a cadmium-binding protein (CdBP). The CdBP appears to elute in a position slightly lower in molecular weight than mammalian metallothionein, contains thiol, and upon ion-exchange chromatography elutes in multiple peaks at ionic strengths greater than mammalian metallothioneins. The remaining cadmium is associated with high molecular weight components. Cytosolic zinc is found primarily (> 80%) in a low molecular weight peak distinct from cadmium, with the remainder as high molecular weight species. As the cells become zinc-deficient and cease proliferation, zinc is lost from the low molecular weight peak while, based on cytosolic protein, the zinc content of the high molecular weight peak remains essentially constant." @default.
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- W2063974379 date "1984-01-01" @default.
- W2063974379 modified "2023-09-27" @default.
- W2063974379 title "Zinc and cadmium metabolism in euglena gracilis: Metal distribution in normal and zinc-deficient cells" @default.
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- W2063974379 doi "https://doi.org/10.1016/0141-1136(84)90072-2" @default.
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