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- W2063976122 abstract "Epidermolytic hyperkeratosis (EH) in man is a complex of congenital, ichthyosiform skin diseases characterized clinically by blistering and hyperkeratosis. These clinical signs are the result of a collapse of the cytoskeleton, seen ultrastructurally as tonofilament clumping and cytolysis within terminally differentiating epidermal cells. In man, specific mutations in keratin 1, 2e, 9 or 10 underlie the various types of EH. This report describes the clinical, histopathological, immunohistochemical and ultrastructural findings in a 6-month-old dog with severe multifocal hyperkeratosis. The morphological changes were comparable with those of EH in man, indicating that this disease, presumably with a similar underlying pathogenetic mechanism, also occurs in the dog." @default.
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- W2063976122 date "2000-04-01" @default.
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- W2063976122 title "SHORT PAPER — Epidermolytic Ichthyosis in a Dog: Clinical, Histopathological, Immunohistochemical and Ultrastructural Findings" @default.
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- W2063976122 doi "https://doi.org/10.1053/jcpa.1999.0371" @default.
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