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• W2063982393 abstract "We designed and synthesized new analogues containing 1,2-dithiolane-3-alkyl and protected or free catechol moieties connected through heteroaromatic rings such as triazole, 1,2,4-oxadiazole, 1,3,4-oxadiazole, tetrazole or thiazole in order to explore the influence of the bioisosteric replacement of the amide group on the neuroprotective activity of the lipoic acid/dopamine conjugate. Evaluation of the activity of the new compounds, using glutamate-challenged hippocampal HT22 cells, showed that incorporation of heteroaromatic rings in the alkyl-1,2-dithiolane moieties in conjunction with another antioxidant, in this case catechol, may result in strong neuroprotective activity." @default.
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• W2063982393 date "2007-08-01" @default.
• W2063982393 modified "2023-09-23" @default.
• W2063982393 title "Design and synthesis of 1,2-dithiolane derivatives and evaluation of their neuroprotective activity" @default.
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• W2063982393 doi "https://doi.org/10.1016/j.bmcl.2007.05.036" @default.
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