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- W2063983669 abstract "Influenza viruses are important pathogens for humans and the discovery of novel anti-influenza drugs with low toxicity deserves great efforts. Fullerenes have attracted considerable attention in different fields of sciences including antiviral activity. We synthesized a fullerene-liposome incorporated compound and investigated its antiviral activity on influenza virus infection in a mouse model. The results showed that fullerene-liposome could reduce mean pulmonary virus yields, decrease the lung index and eventually significantly prolong mean time to death (MTD) and decrease mortality of H1N1 virus-infected mice. Our data indicated that fullerene-liposome has the anti-influenza activity in vivo at much lower concentrations as compared to the Rimantadine, and then reveals that fullerene-liposome is a promising agent in the clinical therapy of influenza infection with favorable water-solubility and low toxicity. Key words: Fullerene-liposome, influenza virus infection, antiviral activity" @default.
- W2063983669 created "2016-06-24" @default.
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- W2063983669 date "2012-02-16" @default.
- W2063983669 modified "2023-09-26" @default.
- W2063983669 title "The antiviral effect of fullerene-liposome complex against influenza virus (H1N1) in vivo" @default.
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- W2063983669 doi "https://doi.org/10.5897/sre11.1927" @default.
- W2063983669 hasPublicationYear "2012" @default.
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