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- W2063991104 abstract "Inflammation plays a role in the pathogenesis of cardiovascular diseases. Viruses may be a cause of chronic inflammation, and both influenza virus and CMV have been associated with cardiovascular diseases. IL-6, a proinflammatory cytokine with antiviral effects, has a pivotal role in the immune response, and under pathologic conditions, prohemostatic effects of IL-6 could lead to pathologic thrombosis and vascular plaque instability. To investigate this role of IL-6, we measured the production of IL-6 by human endothelial cells after infection with influenza virus and CMV. After infection with influenza virus or CMV, IL-6 release into the medium increased (1756.5+/-156.9 pg/mL vs 284.4+/-55.3 pg/mL; P < .001) for influenza-Infected compared with uninfected cells after 36 hours' incubation. Ultracentrifuged influenza virus supernatants, heat-inactivated virus, and purified hemagglutinin were not able to elicit IL-6 synthesis by human endothelial cells. These findings show that CMV and influenza virus are capable of modulating the in vitro production of IL-6, a cytokine involved in vascular inflammation, by human endothelial cells." @default.
- W2063991104 created "2016-06-24" @default.
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- W2063991104 date "1999-12-01" @default.
- W2063991104 modified "2023-09-27" @default.
- W2063991104 title "Interleukin-6 production by endothelial cells after infection with influenza virus and cytomegalovirus" @default.
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- W2063991104 doi "https://doi.org/10.1016/s0022-2143(99)90103-8" @default.
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