Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063999671> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2063999671 endingPage "575" @default.
- W2063999671 startingPage "567" @default.
- W2063999671 abstract "The induction of hepatic P-450 hemoprotein-dependent mono-oxygenase systems was studied in fetal and neonatal rats. The fetal liver was refractive to phenobarbital induction of aminopyrine and ethylmorphine N-demethylase. which are cytochrome P-450-dependent mono-oxygenases, but was not refractive to the 3-methylcholanthrene induction of benzo[a]pyrene hydroxylase. a cytochrome P1-450-dependent mono-oxygenase. After parturition, all three enzyme activities were inducible. These and other observations suggest that a control mechanism operates in the fetal rat which selectively suppresses the induction of cytochrome P-450. but allows induction of cytochrome P1-450. This selective suppression of phenobarbital induction in the fetus was reversed in part by the simultaneous administration of 3-methylcholanthrene. Several other inducing agents also partially reversed the suppression of phonobarbital induction in Fetal livers: dibenz-[a,c]anthracene, 2-diethylaminoethyl-2.2-diphenyl-valerate (SKF 525-A), and 3β-hydroxy-20-oxopregn-5-ene-16α-carbonitrile (PCN). Other inducing agents were inactive: α-naphthoflavone, β-naphthoflavone. 1,1-bis[p-chlorophenyl]2,2,2-trichloroethane (DDT). 2,4,5-trichlorophenoxyacetic acid (2,4,5-T). dieldrin. chlordane and chlorpromazine." @default.
- W2063999671 created "2016-06-24" @default.
- W2063999671 creator A5024412867 @default.
- W2063999671 creator A5031547937 @default.
- W2063999671 date "1977-04-01" @default.
- W2063999671 modified "2023-09-23" @default.
- W2063999671 title "Induction of hepatic mono-oxygenase systems in fetal and neonatal rats with phenobarbital, polycyclic hydrocarbons and other xenobiotics" @default.
- W2063999671 cites W126145571 @default.
- W2063999671 cites W1604536885 @default.
- W2063999671 cites W1775749144 @default.
- W2063999671 cites W1994800122 @default.
- W2063999671 cites W1995993782 @default.
- W2063999671 cites W2002443919 @default.
- W2063999671 cites W2007119595 @default.
- W2063999671 cites W2007427482 @default.
- W2063999671 cites W2008931598 @default.
- W2063999671 cites W2012200670 @default.
- W2063999671 cites W2014788874 @default.
- W2063999671 cites W2028697588 @default.
- W2063999671 cites W2044703662 @default.
- W2063999671 cites W2047404468 @default.
- W2063999671 cites W2050891806 @default.
- W2063999671 cites W2055834016 @default.
- W2063999671 cites W2060524386 @default.
- W2063999671 cites W2063869411 @default.
- W2063999671 cites W2083427923 @default.
- W2063999671 cites W2411145959 @default.
- W2063999671 cites W51442476 @default.
- W2063999671 doi "https://doi.org/10.1016/0006-2952(77)90026-0" @default.
- W2063999671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/405011" @default.
- W2063999671 hasPublicationYear "1977" @default.
- W2063999671 type Work @default.
- W2063999671 sameAs 2063999671 @default.
- W2063999671 citedByCount "72" @default.
- W2063999671 crossrefType "journal-article" @default.
- W2063999671 hasAuthorship W2063999671A5024412867 @default.
- W2063999671 hasAuthorship W2063999671A5031547937 @default.
- W2063999671 hasConcept C126322002 @default.
- W2063999671 hasConcept C132154277 @default.
- W2063999671 hasConcept C161176658 @default.
- W2063999671 hasConcept C165474305 @default.
- W2063999671 hasConcept C172680121 @default.
- W2063999671 hasConcept C181199279 @default.
- W2063999671 hasConcept C185592680 @default.
- W2063999671 hasConcept C2776640376 @default.
- W2063999671 hasConcept C2778793413 @default.
- W2063999671 hasConcept C2779234561 @default.
- W2063999671 hasConcept C2780753045 @default.
- W2063999671 hasConcept C2780768313 @default.
- W2063999671 hasConcept C54355233 @default.
- W2063999671 hasConcept C55493867 @default.
- W2063999671 hasConcept C6557445 @default.
- W2063999671 hasConcept C71924100 @default.
- W2063999671 hasConcept C86803240 @default.
- W2063999671 hasConcept C98274493 @default.
- W2063999671 hasConceptScore W2063999671C126322002 @default.
- W2063999671 hasConceptScore W2063999671C132154277 @default.
- W2063999671 hasConceptScore W2063999671C161176658 @default.
- W2063999671 hasConceptScore W2063999671C165474305 @default.
- W2063999671 hasConceptScore W2063999671C172680121 @default.
- W2063999671 hasConceptScore W2063999671C181199279 @default.
- W2063999671 hasConceptScore W2063999671C185592680 @default.
- W2063999671 hasConceptScore W2063999671C2776640376 @default.
- W2063999671 hasConceptScore W2063999671C2778793413 @default.
- W2063999671 hasConceptScore W2063999671C2779234561 @default.
- W2063999671 hasConceptScore W2063999671C2780753045 @default.
- W2063999671 hasConceptScore W2063999671C2780768313 @default.
- W2063999671 hasConceptScore W2063999671C54355233 @default.
- W2063999671 hasConceptScore W2063999671C55493867 @default.
- W2063999671 hasConceptScore W2063999671C6557445 @default.
- W2063999671 hasConceptScore W2063999671C71924100 @default.
- W2063999671 hasConceptScore W2063999671C86803240 @default.
- W2063999671 hasConceptScore W2063999671C98274493 @default.
- W2063999671 hasIssue "7" @default.
- W2063999671 hasLocation W20639996711 @default.
- W2063999671 hasLocation W20639996712 @default.
- W2063999671 hasOpenAccess W2063999671 @default.
- W2063999671 hasPrimaryLocation W20639996711 @default.
- W2063999671 hasRelatedWork W1990811403 @default.
- W2063999671 hasRelatedWork W1996426409 @default.
- W2063999671 hasRelatedWork W2035534701 @default.
- W2063999671 hasRelatedWork W2035929428 @default.
- W2063999671 hasRelatedWork W2042380097 @default.
- W2063999671 hasRelatedWork W2131888925 @default.
- W2063999671 hasRelatedWork W2204962900 @default.
- W2063999671 hasRelatedWork W2277896878 @default.
- W2063999671 hasRelatedWork W2399357403 @default.
- W2063999671 hasRelatedWork W2412619217 @default.
- W2063999671 hasVolume "26" @default.
- W2063999671 isParatext "false" @default.
- W2063999671 isRetracted "false" @default.
- W2063999671 magId "2063999671" @default.
- W2063999671 workType "article" @default.