FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064022012> ?p ?o ?g. }

• W2064022012 endingPage "618" @default.
• W2064022012 startingPage "612" @default.
• W2064022012 abstract "Radioiodide is an effective therapy for thyroid cancer. This treatment modality exploits the thyroid-specific expression of the sodium iodide symporter (NIS) gene, which allows rapid internalization of iodide into thyroid cells. To test whether a similar treatment strategy could be exploited in nonthyroid malignancies, we transfected non-small cell lung cancer (NSCLC) cell lines with the NIS gene. Although the expression of NIS allowed significant radioiodide uptake in the transfected NSCLC cell lines, rapid radioiodide efflux limited tumor cell killing. Because thyroperoxidase (TPO) catalyzes iodination of proteins and subsequently causes iodide retention within thyroid cells, we hypothesized that coexpression of both NIS and TPO genes would overcome this deficiency. Our results show that transfection of NSCLC cells with both human NIS and TPO genes resulted in an increase in radioiodide uptake and retention and enhanced tumor cell apoptosis. These findings suggest that single gene therapy with only the NIS gene may have limited efficacy because of rapid efflux of radioiodide. In contrast, the combination of NIS and TPO gene transfer, with resulting TPO-mediated organification and intracellular retention of radioiodide, may lead to more effective tumor cell death. Thus, TPO could be used as a therapeutic strategy to enhance the NIS-based radioiodide concentrator gene therapy for locally advanced lung cancer." @default.
• W2064022012 created "2016-06-24" @default.
• W2064022012 creator A5026644618 @default.
• W2064022012 creator A5032200826 @default.
• W2064022012 creator A5047381228 @default.
• W2064022012 creator A5049222616 @default.
• W2064022012 creator A5053750107 @default.
• W2064022012 creator A5058506032 @default.
• W2064022012 creator A5059818425 @default.
• W2064022012 creator A5073274148 @default.
• W2064022012 creator A5087352271 @default.
• W2064022012 creator A5089009048 @default.
• W2064022012 date "2001-08-01" @default.
• W2064022012 modified "2023-10-18" @default.
• W2064022012 title "Ectopic expression of the thyroperoxidase gene augments radioiodide uptake and retention mediated by the sodium iodide symporter in non–small cell lung cancer" @default.
• W2064022012 cites W1608070656 @default.
• W2064022012 cites W1891172846 @default.
• W2064022012 cites W1964366490 @default.
• W2064022012 cites W2014571061 @default.
• W2064022012 cites W2015554237 @default.
• W2064022012 cites W2039518748 @default.
• W2064022012 cites W2046088133 @default.
• W2064022012 cites W2047516670 @default.
• W2064022012 cites W2072716278 @default.
• W2064022012 cites W2083350201 @default.
• W2064022012 cites W2101651692 @default.
• W2064022012 cites W2103151868 @default.
• W2064022012 cites W2134781138 @default.
• W2064022012 cites W2140052472 @default.
• W2064022012 cites W2147943356 @default.
• W2064022012 cites W2151428570 @default.
• W2064022012 cites W2161469472 @default.
• W2064022012 cites W2333841029 @default.
• W2064022012 cites W2470137133 @default.
• W2064022012 cites W2527215646 @default.
• W2064022012 doi "https://doi.org/10.1038/sj.cgt.7700354" @default.
• W2064022012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1471880" @default.
• W2064022012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11571539" @default.
• W2064022012 hasPublicationYear "2001" @default.
• W2064022012 type Work @default.
• W2064022012 sameAs 2064022012 @default.
• W2064022012 citedByCount "118" @default.
• W2064022012 countsByYear W20640220122012 @default.
• W2064022012 countsByYear W20640220122013 @default.
• W2064022012 countsByYear W20640220122014 @default.
• W2064022012 countsByYear W20640220122015 @default.
• W2064022012 countsByYear W20640220122016 @default.
• W2064022012 countsByYear W20640220122017 @default.
• W2064022012 countsByYear W20640220122019 @default.
• W2064022012 countsByYear W20640220122020 @default.
• W2064022012 countsByYear W20640220122021 @default.
• W2064022012 countsByYear W20640220122022 @default.
• W2064022012 countsByYear W20640220122023 @default.
• W2064022012 crossrefType "journal-article" @default.
• W2064022012 hasAuthorship W2064022012A5026644618 @default.
• W2064022012 hasAuthorship W2064022012A5032200826 @default.
• W2064022012 hasAuthorship W2064022012A5047381228 @default.
• W2064022012 hasAuthorship W2064022012A5049222616 @default.
• W2064022012 hasAuthorship W2064022012A5053750107 @default.
• W2064022012 hasAuthorship W2064022012A5058506032 @default.
• W2064022012 hasAuthorship W2064022012A5059818425 @default.
• W2064022012 hasAuthorship W2064022012A5073274148 @default.
• W2064022012 hasAuthorship W2064022012A5087352271 @default.
• W2064022012 hasAuthorship W2064022012A5089009048 @default.
• W2064022012 hasBestOaLocation W20640220121 @default.
• W2064022012 hasConcept C104317684 @default.
• W2064022012 hasConcept C120405084 @default.
• W2064022012 hasConcept C126322002 @default.
• W2064022012 hasConcept C134018914 @default.
• W2064022012 hasConcept C149011108 @default.
• W2064022012 hasConcept C180650514 @default.
• W2064022012 hasConcept C185592680 @default.
• W2064022012 hasConcept C2779123554 @default.
• W2064022012 hasConcept C2779761222 @default.
• W2064022012 hasConcept C2780616701 @default.
• W2064022012 hasConcept C502942594 @default.
• W2064022012 hasConcept C526584372 @default.
• W2064022012 hasConcept C54009773 @default.
• W2064022012 hasConcept C55493867 @default.
• W2064022012 hasConcept C71924100 @default.
• W2064022012 hasConcept C86803240 @default.
• W2064022012 hasConceptScore W2064022012C104317684 @default.
• W2064022012 hasConceptScore W2064022012C120405084 @default.
• W2064022012 hasConceptScore W2064022012C126322002 @default.
• W2064022012 hasConceptScore W2064022012C134018914 @default.
• W2064022012 hasConceptScore W2064022012C149011108 @default.
• W2064022012 hasConceptScore W2064022012C180650514 @default.
• W2064022012 hasConceptScore W2064022012C185592680 @default.
• W2064022012 hasConceptScore W2064022012C2779123554 @default.
• W2064022012 hasConceptScore W2064022012C2779761222 @default.
• W2064022012 hasConceptScore W2064022012C2780616701 @default.
• W2064022012 hasConceptScore W2064022012C502942594 @default.
• W2064022012 hasConceptScore W2064022012C526584372 @default.
• W2064022012 hasConceptScore W2064022012C54009773 @default.
• W2064022012 hasConceptScore W2064022012C55493867 @default.
• W2064022012 hasConceptScore W2064022012C71924100 @default.
• W2064022012 hasConceptScore W2064022012C86803240 @default.
• W2064022012 hasIssue "8" @default.

• next