FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064036077> ?p ?o ?g. }

• W2064036077 endingPage "714" @default.
• W2064036077 startingPage "705" @default.
• W2064036077 abstract "Renal tubular Mg(2+) reabsorption is mediated predominantly by the tight junction channel protein claudin-16 which is encoded by the gene CLDN16. Hypermagnesemia decreases, whereas hypomagnesemia increases Mg(2+) reabsorption. This study examines the role of claudin-16 in the adaptive response of the kidney to Mg(2+) availability.Mice received a low-, normal- or high Mg(2+) diet for up to 3 days. Mg(2+)-loaded animals displayed hypermagnesemia with increasing urine Mg(2+)/Ca(2+) levels paralleled by a decrease in claudin-16 protein and mRNA in the kidney. Mg(2+)- deprived animals developed hypomagnesemia with decreasing urine Mg(2+)/Ca(2+) levels associated with an increase in claudin-16 protein and mRNA abundance. Mg(2+) depletion markedly increased and Mg(2+) load decreased endogenous claudin-16 mRNA levels in calcium-sensing receptor-transfected HEK293 cells compared with native HEK293 cells. The effect of Mg(2+) availability on the human CLDN16 (hCLDN16) gene promoter was examined. Using a 2.5kb hCLDN16 5'-flanking DNA sequence, we show that magnesium depletion increases and Mg(2+) load decreases hCLDN16 promoter activity in transfected HEK293 cells.Changes in Mg(2+) availability may influence claudin-16 mediated Mg(2+) transport at the transcriptional level. The possible involvement of the cell membrane bound Ca(2+)/Mg(2+) sensing receptor or the potential role of a hypothetical Mg(2+) response element on the CLDN16 promoter in the Mg(2+)-induced response remains to be explored." @default.
• W2064036077 created "2016-06-24" @default.
• W2064036077 creator A5017400637 @default.
• W2064036077 creator A5021459363 @default.
• W2064036077 creator A5048846156 @default.
• W2064036077 creator A5052790781 @default.
• W2064036077 creator A5062023248 @default.
• W2064036077 creator A5062876899 @default.
• W2064036077 creator A5080726086 @default.
• W2064036077 date "2010-01-01" @default.
• W2064036077 modified "2023-09-25" @default.
• W2064036077 title "Transcriptional Regulation of the Claudin-16 Gene by Mg²⁺Availability" @default.
• W2064036077 cites W1650401181 @default.
• W2064036077 cites W1666469474 @default.
• W2064036077 cites W1840110950 @default.
• W2064036077 cites W1968634646 @default.
• W2064036077 cites W1981688857 @default.
• W2064036077 cites W1997742378 @default.
• W2064036077 cites W2009291880 @default.
• W2064036077 cites W2015603980 @default.
• W2064036077 cites W2016490634 @default.
• W2064036077 cites W2034626424 @default.
• W2064036077 cites W2038412379 @default.
• W2064036077 cites W2038902966 @default.
• W2064036077 cites W2039092096 @default.
• W2064036077 cites W2041230818 @default.
• W2064036077 cites W206190567 @default.
• W2064036077 cites W2080895683 @default.
• W2064036077 cites W2081557881 @default.
• W2064036077 cites W2091422963 @default.
• W2064036077 cites W2093111294 @default.
• W2064036077 cites W2101716998 @default.
• W2064036077 cites W2101937063 @default.
• W2064036077 cites W2106856165 @default.
• W2064036077 cites W2122767942 @default.
• W2064036077 cites W2135392057 @default.
• W2064036077 cites W2139363250 @default.
• W2064036077 cites W2154694053 @default.
• W2064036077 cites W2164188937 @default.
• W2064036077 cites W2183045693 @default.
• W2064036077 cites W2273862599 @default.
• W2064036077 cites W2410128019 @default.
• W2064036077 cites W2440455077 @default.
• W2064036077 cites W3158161143 @default.
• W2064036077 doi "https://doi.org/10.1159/000315090" @default.
• W2064036077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20511716" @default.
• W2064036077 hasPublicationYear "2010" @default.
• W2064036077 type Work @default.
• W2064036077 sameAs 2064036077 @default.
• W2064036077 citedByCount "15" @default.
• W2064036077 countsByYear W20640360772012 @default.
• W2064036077 countsByYear W20640360772013 @default.
• W2064036077 countsByYear W20640360772014 @default.
• W2064036077 countsByYear W20640360772016 @default.
• W2064036077 countsByYear W20640360772018 @default.
• W2064036077 countsByYear W20640360772019 @default.
• W2064036077 countsByYear W20640360772021 @default.
• W2064036077 countsByYear W20640360772023 @default.
• W2064036077 crossrefType "journal-article" @default.
• W2064036077 hasAuthorship W2064036077A5017400637 @default.
• W2064036077 hasAuthorship W2064036077A5021459363 @default.
• W2064036077 hasAuthorship W2064036077A5048846156 @default.
• W2064036077 hasAuthorship W2064036077A5052790781 @default.
• W2064036077 hasAuthorship W2064036077A5062023248 @default.
• W2064036077 hasAuthorship W2064036077A5062876899 @default.
• W2064036077 hasAuthorship W2064036077A5080726086 @default.
• W2064036077 hasBestOaLocation W20640360771 @default.
• W2064036077 hasConcept C104317684 @default.
• W2064036077 hasConcept C105580179 @default.
• W2064036077 hasConcept C126322002 @default.
• W2064036077 hasConcept C134018914 @default.
• W2064036077 hasConcept C150194340 @default.
• W2064036077 hasConcept C153911025 @default.
• W2064036077 hasConcept C170493617 @default.
• W2064036077 hasConcept C174510640 @default.
• W2064036077 hasConcept C177779419 @default.
• W2064036077 hasConcept C178790620 @default.
• W2064036077 hasConcept C185592680 @default.
• W2064036077 hasConcept C2776183862 @default.
• W2064036077 hasConcept C2776492347 @default.
• W2064036077 hasConcept C2780091579 @default.
• W2064036077 hasConcept C51872919 @default.
• W2064036077 hasConcept C54009773 @default.
• W2064036077 hasConcept C543218039 @default.
• W2064036077 hasConcept C55493867 @default.
• W2064036077 hasConcept C56906281 @default.
• W2064036077 hasConcept C71924100 @default.
• W2064036077 hasConcept C86803240 @default.
• W2064036077 hasConceptScore W2064036077C104317684 @default.
• W2064036077 hasConceptScore W2064036077C105580179 @default.
• W2064036077 hasConceptScore W2064036077C126322002 @default.
• W2064036077 hasConceptScore W2064036077C134018914 @default.
• W2064036077 hasConceptScore W2064036077C150194340 @default.
• W2064036077 hasConceptScore W2064036077C153911025 @default.
• W2064036077 hasConceptScore W2064036077C170493617 @default.
• W2064036077 hasConceptScore W2064036077C174510640 @default.
• W2064036077 hasConceptScore W2064036077C177779419 @default.
• W2064036077 hasConceptScore W2064036077C178790620 @default.

• next