Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064036514> ?p ?o ?g. }
- W2064036514 endingPage "282" @default.
- W2064036514 startingPage "229" @default.
- W2064036514 abstract "Increasing evidence has suggested that arterial adventitia may contribute to pathological vessel remodeling by producing reactive oxygen species and promoting neovascularization. However, these processes have not been studied yet in transplantation-induced vascular pathologies. We characterized the dynamic changes in NADPH oxidase expression and adventitial angiogenic response in a model of allograft aortic transplantation. The thoracic aorta from Fischer 344 rats were transplanted into the abdominal aorta of Lewis rats. Graft specimens were collected on days 0.5, 3, 7, and 14 for morphometry, immunohistochemistry, immunofluorescence staining, and quantitative PCR tests. Following transplantation, adventitial thickening was found as early as day 3, while neointima was observed from day 7. As compared to normal adventitial tissue, the expression levels of NADPH oxidase subunits gp91phox and p47phox in graft adventitia were elevated from day 3 and further increased up to day 14. Immunohistochemistry staining showed that infiltrating macrophages appeared to be a major source of NADPH oxidase expression. Increases in NADPH oxidase expression were also detected in fibroblasts isolated from the graft adventitia. Gene silencing of p47phox significantly suppressed proliferation and migration of the graft fibroblast cells. We also showed that adventitial thickening was accompanied by increased adventitial neovascularization; at day 14, there was a positive correlation between the density of adventitial microvessels and the neointimal thickness. Transplantation injury induces NADPH oxidase expression and neovascularization in the adventitia, raising the possibility that the activated adventitia may represent a target site for prevention of transplantation-induced transplant vasculopathy." @default.
- W2064036514 created "2016-06-24" @default.
- W2064036514 creator A5078723091 @default.
- W2064036514 date "1991-01-01" @default.
- W2064036514 modified "2023-09-27" @default.
- W2064036514 title "Long-term complications of cardiac transplantation" @default.
- W2064036514 cites W123024795 @default.
- W2064036514 cites W1963486323 @default.
- W2064036514 cites W1964412286 @default.
- W2064036514 cites W1964619870 @default.
- W2064036514 cites W1964718311 @default.
- W2064036514 cites W1965139242 @default.
- W2064036514 cites W1965486287 @default.
- W2064036514 cites W1965551695 @default.
- W2064036514 cites W1966176590 @default.
- W2064036514 cites W1968347512 @default.
- W2064036514 cites W1969017982 @default.
- W2064036514 cites W1969034886 @default.
- W2064036514 cites W1969535537 @default.
- W2064036514 cites W1970003185 @default.
- W2064036514 cites W1970051408 @default.
- W2064036514 cites W1971181065 @default.
- W2064036514 cites W1971489644 @default.
- W2064036514 cites W1972460452 @default.
- W2064036514 cites W1973136343 @default.
- W2064036514 cites W1974729318 @default.
- W2064036514 cites W1975051725 @default.
- W2064036514 cites W1975759226 @default.
- W2064036514 cites W1975888483 @default.
- W2064036514 cites W1976060163 @default.
- W2064036514 cites W1976129849 @default.
- W2064036514 cites W1976761972 @default.
- W2064036514 cites W1977260184 @default.
- W2064036514 cites W1977448179 @default.
- W2064036514 cites W1977731537 @default.
- W2064036514 cites W1979050172 @default.
- W2064036514 cites W1979871383 @default.
- W2064036514 cites W1980665955 @default.
- W2064036514 cites W1980868360 @default.
- W2064036514 cites W1981081771 @default.
- W2064036514 cites W1982160963 @default.
- W2064036514 cites W1982654128 @default.
- W2064036514 cites W1983098285 @default.
- W2064036514 cites W1983322810 @default.
- W2064036514 cites W1984404379 @default.
- W2064036514 cites W1984450730 @default.
- W2064036514 cites W1984520474 @default.
- W2064036514 cites W1985086542 @default.
- W2064036514 cites W1985246817 @default.
- W2064036514 cites W1985729934 @default.
- W2064036514 cites W1986152422 @default.
- W2064036514 cites W1986575784 @default.
- W2064036514 cites W1986626576 @default.
- W2064036514 cites W1986772541 @default.
- W2064036514 cites W1987257894 @default.
- W2064036514 cites W1987622195 @default.
- W2064036514 cites W1988259336 @default.
- W2064036514 cites W1989400464 @default.
- W2064036514 cites W1990201182 @default.
- W2064036514 cites W1991356164 @default.
- W2064036514 cites W1993051112 @default.
- W2064036514 cites W1993082334 @default.
- W2064036514 cites W1993303487 @default.
- W2064036514 cites W1993519091 @default.
- W2064036514 cites W1993628968 @default.
- W2064036514 cites W1994220211 @default.
- W2064036514 cites W1996626172 @default.
- W2064036514 cites W1996842876 @default.
- W2064036514 cites W1996960615 @default.
- W2064036514 cites W1997061031 @default.
- W2064036514 cites W1997271863 @default.
- W2064036514 cites W1997885157 @default.
- W2064036514 cites W1997911871 @default.
- W2064036514 cites W1998892072 @default.
- W2064036514 cites W2000179181 @default.
- W2064036514 cites W2000460086 @default.
- W2064036514 cites W2000628798 @default.
- W2064036514 cites W2000705732 @default.
- W2064036514 cites W2002014784 @default.
- W2064036514 cites W2002057403 @default.
- W2064036514 cites W2002090750 @default.
- W2064036514 cites W2002214885 @default.
- W2064036514 cites W2003190704 @default.
- W2064036514 cites W2003844924 @default.
- W2064036514 cites W2003917740 @default.
- W2064036514 cites W2004629165 @default.
- W2064036514 cites W2005699040 @default.
- W2064036514 cites W2005909395 @default.
- W2064036514 cites W2007212857 @default.
- W2064036514 cites W2007734656 @default.
- W2064036514 cites W2007775417 @default.
- W2064036514 cites W2007957083 @default.
- W2064036514 cites W2008032845 @default.
- W2064036514 cites W2009844134 @default.
- W2064036514 cites W2010488262 @default.
- W2064036514 cites W2011119992 @default.
- W2064036514 cites W2011559801 @default.
- W2064036514 cites W2011786679 @default.