FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064036617> ?p ?o ?g. }

• W2064036617 endingPage "428" @default.
• W2064036617 startingPage "421" @default.
• W2064036617 abstract "Because randomized trials have shown a reduction in breast cancer mortality, analog mammography for the early detection of breast cancer has gained widespread use. Recently, several manufacturers have developed digital mammography, which promises great advantages in the storage and transmission of images. We were asked to design a study to compare the two types of mammography in terms of their performance for the early detection of breast cancer. A standard measure of mammography performance is the receiver operating characteristic (ROC) curve, which is a plot of false- and true-positive rates for each ordered classification of the mammography images. Methods for study design and data analysis based on ROC curves have been well developed for diagnostic tests, particularly in radiology. But for comparing the performance of mammography for the early detection of breast cancer among asymptomatic women, special considerations motivate new designs and methodology. First, digital mammography may cost substantially more than analog mammography. If this is the case, then the standard paired design, in which each subject undergoes both types of mammography, may be more expensive than necessary. To reduce costs, we propose a partial testing design, in which all subjects undergo analog mammography and those recommended for biopsy and a random sample not recommended for biopsy also undergo digital mammography. Second, the false-positive rate for analog mammography, defined as the rate of unnecessary biopsy, is near 1%. A standard ROC analysis that compares areas under the entire ROC curve would summarize performance over false-positive rates that are not relevant for evaluating the performance of cancer screening. As a more appropriate alternative, we propose basing inference on the areas under the small part of the ROC curves near the false-positive rates corresponding to a biopsy recommendation. Third, the vast majority of screened subjects are not biopsied, and so have an unknown cancer state at the time of screening. To make inference about the performance of a cancer screening test, the standard approach is to follow subjects not biopsied for some period, usually 1 year, and assume that those who developed cancer were missed on screening and those who did not develop cancer were cancer-free at screening. Unfortunately, this follow-up period can greatly lengthen the duration of the study. To compare the performance of digital and analog mammography without the need for a follow-up period, we propose estimating the ratio of areas under the ROC curves near the small false-positive rates associated with a biopsy recommendation. To compute sample sizes, our null hypothesis is that the ratio of partial ROC areas is 1, and our two possible alternative hypotheses are ratios of 1.6 and 2, both indicating superior performance for digital mammography. We assume a breast cancer prevalence of .003 and specify various parameters for the shapes of the ROC curves and their dependence. For a two-sided type I error of .05 and a power of .9, a standard paired design would require that 22,000 subjects undergo both analog and digital mammography. For the same type I error and power, the proposed partial testing design would require that 35,000 subjects undergo analog mammography and 10,000 subjects undergo both analog and digital mammography. Compared to the paired design, the reduction in the cost per subject is 23% if digital mammography costs four times as much as analog mammography and 41% if digital mammography costs 10 times as much as analog mammography." @default.
• W2064036617 created "2016-06-24" @default.
• W2064036617 creator A5001740944 @default.
• W2064036617 creator A5053628150 @default.
• W2064036617 date "2001-06-01" @default.
• W2064036617 modified "2023-09-24" @default.
• W2064036617 title "A Proposed Design and Analysis for Comparing Digital and Analog Mammography" @default.
• W2064036617 cites W147015258 @default.
• W2064036617 cites W1921869839 @default.
• W2064036617 cites W1953074041 @default.
• W2064036617 cites W1966095176 @default.
• W2064036617 cites W1988264599 @default.
• W2064036617 cites W1990534247 @default.
• W2064036617 cites W1990748933 @default.
• W2064036617 cites W1998307574 @default.
• W2064036617 cites W2035950812 @default.
• W2064036617 cites W2037711351 @default.
• W2064036617 cites W2041856815 @default.
• W2064036617 cites W2051269613 @default.
• W2064036617 cites W2054623389 @default.
• W2064036617 cites W2057335587 @default.
• W2064036617 cites W2064339892 @default.
• W2064036617 cites W2071389756 @default.
• W2064036617 cites W2078622638 @default.
• W2064036617 cites W2084508140 @default.
• W2064036617 cites W2087963968 @default.
• W2064036617 cites W2098985260 @default.
• W2064036617 cites W2118056643 @default.
• W2064036617 cites W2123892251 @default.
• W2064036617 cites W2126804515 @default.
• W2064036617 cites W2152972027 @default.
• W2064036617 cites W2157825442 @default.
• W2064036617 cites W2166070444 @default.
• W2064036617 cites W2316306635 @default.
• W2064036617 cites W2325332048 @default.
• W2064036617 cites W2335503264 @default.
• W2064036617 cites W2464723405 @default.
• W2064036617 cites W2498287392 @default.
• W2064036617 cites W4236953343 @default.
• W2064036617 cites W4240563447 @default.
• W2064036617 doi "https://doi.org/10.1198/016214501753168136" @default.
• W2064036617 hasPublicationYear "2001" @default.
• W2064036617 type Work @default.
• W2064036617 sameAs 2064036617 @default.
• W2064036617 citedByCount "48" @default.
• W2064036617 countsByYear W20640366172012 @default.
• W2064036617 countsByYear W20640366172013 @default.
• W2064036617 countsByYear W20640366172014 @default.
• W2064036617 countsByYear W20640366172015 @default.
• W2064036617 countsByYear W20640366172016 @default.
• W2064036617 countsByYear W20640366172017 @default.
• W2064036617 countsByYear W20640366172018 @default.
• W2064036617 countsByYear W20640366172020 @default.
• W2064036617 countsByYear W20640366172022 @default.
• W2064036617 countsByYear W20640366172023 @default.
• W2064036617 crossrefType "journal-article" @default.
• W2064036617 hasAuthorship W2064036617A5001740944 @default.
• W2064036617 hasAuthorship W2064036617A5053628150 @default.
• W2064036617 hasConcept C121608353 @default.
• W2064036617 hasConcept C126322002 @default.
• W2064036617 hasConcept C126838900 @default.
• W2064036617 hasConcept C19527891 @default.
• W2064036617 hasConcept C2780472235 @default.
• W2064036617 hasConcept C2781281974 @default.
• W2064036617 hasConcept C530470458 @default.
• W2064036617 hasConcept C58471807 @default.
• W2064036617 hasConcept C71924100 @default.
• W2064036617 hasConceptScore W2064036617C121608353 @default.
• W2064036617 hasConceptScore W2064036617C126322002 @default.
• W2064036617 hasConceptScore W2064036617C126838900 @default.
• W2064036617 hasConceptScore W2064036617C19527891 @default.
• W2064036617 hasConceptScore W2064036617C2780472235 @default.
• W2064036617 hasConceptScore W2064036617C2781281974 @default.
• W2064036617 hasConceptScore W2064036617C530470458 @default.
• W2064036617 hasConceptScore W2064036617C58471807 @default.
• W2064036617 hasConceptScore W2064036617C71924100 @default.
• W2064036617 hasIssue "454" @default.
• W2064036617 hasLocation W20640366171 @default.
• W2064036617 hasOpenAccess W2064036617 @default.
• W2064036617 hasPrimaryLocation W20640366171 @default.
• W2064036617 hasRelatedWork W1766776469 @default.
• W2064036617 hasRelatedWork W1990413141 @default.
• W2064036617 hasRelatedWork W1991301240 @default.
• W2064036617 hasRelatedWork W1992072519 @default.
• W2064036617 hasRelatedWork W2159722994 @default.
• W2064036617 hasRelatedWork W2168644477 @default.
• W2064036617 hasRelatedWork W2348133101 @default.
• W2064036617 hasRelatedWork W3120100606 @default.
• W2064036617 hasRelatedWork W1680833940 @default.
• W2064036617 hasRelatedWork W2116047071 @default.
• W2064036617 hasVolume "96" @default.
• W2064036617 isParatext "false" @default.
• W2064036617 isRetracted "false" @default.
• W2064036617 magId "2064036617" @default.
• W2064036617 workType "article" @default.