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- W2064036732 abstract "Twenty-four patients with chronic drug resistant pulmonary tuberculosis were included in a ‘double-blind’ trial of cycloserine. Sixteen patients were originally in the treatment group receiving cycloserine-isoniazid capsules, but three were removed as the trial progressed. There were eight patients in the control group receiving isoniazid alone at the start of the trial, and two of these were removed later. The trial consisted of one month in-patient and eleven months out-patient treatment, with a follow-up period of six months. The dosage of cycloserine was 250 mg. twelve hourly and of isoniazid 150 mg. twelve hourly. Ten patients in the cycloserine group showed striking weight gains, seven pronounced clinical improvement and four radiographic improvement, compared with one patient showing such change in the control group. Temporary sputum ‘conversion’ occurred in only three of the cycloserine group patients. Toxic effects occurred in nine out of 16 cycloserine group patients; the drug was with-drawn in three. Five out of eight patients in the control series also compalined of symptoms, the treatment having to be discontinued in two. In a dosage of 250 mg. twelve hourly, cycloserine was used without serious toxic effects, and this dose was considered safe for use in out-patients. In the three patients with detailed sputum sensitivity tests available two developed cultures with cycloserine resistance eight times that of the control strain H37Rv. after twelve months treatment, and this degree of resistance remained throughout the six months follow-up period." @default.
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- W2064036732 date "1961-03-01" @default.
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- W2064036732 title "Cycloserine treatment of out-patients with chronic drug resistant pulmonary tuberculosis" @default.
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- W2064036732 doi "https://doi.org/10.1016/s0041-3879(61)80011-1" @default.
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