FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064037332> ?p ?o ?g. }

• W2064037332 endingPage "296" @default.
• W2064037332 startingPage "289" @default.
• W2064037332 abstract "The feasibility of using antigenically disguised skin xenotransplants to cover extensive burns for a suitable time lag without administering immunosuppressive drugs was tested experimentally. Pieces of human skin that had been preincubated for 3 h at 37°C with either mouse anti-human β2-microglobulin monoclonal antibody (β2m-McAb) or PBS (controls) were grafted onto the backs of immunologically competent Swiss mice, and the time required for their rejection or substitution by normal autogenous skin was determined. Thus, it was found that the β2m-McAb-pretreated xenografts had a significantly longer mean survival time than the control grafts. An even longer skin xenograft MST was obtained when β2m-McAb was repeatedly injected, at weekly intervals, just beneath the transplants. Parallel immunohistochemical studies showed that the β2m-McAb entered the grafts and was bound to its targets both in epidermis and dermis. Moreover, a small amount of β2m-McAb administered at the outset significantly hindered the reactive proliferation of primed mouse spleen cells cultured in the presence of human epidermal cells. Finally, neither toxic effects nor a weakening of immune competence were elicited by repeated intraperitoneal injections of β2m-McAb. Therefore, it seems expedient to propose the use of β2m-McAb to delay the rejection of skin xenografts as this antibody harmlessly prevents, wholly or in part, the activation of the recipients' lymphocytes. This would positively aid any patient urgently needing xenograft cover of extensive burns." @default.
• W2064037332 created "2016-06-24" @default.
• W2064037332 creator A5001509020 @default.
• W2064037332 creator A5030009904 @default.
• W2064037332 creator A5049475413 @default.
• W2064037332 creator A5052407008 @default.
• W2064037332 creator A5086685012 @default.
• W2064037332 date "1993-08-01" @default.
• W2064037332 modified "2023-09-26" @default.
• W2064037332 title "A novel approach to extend the survival of skin xenografts without entailing general immunosuppression or systemic toxicity" @default.
• W2064037332 cites W119193490 @default.
• W2064037332 cites W1551614022 @default.
• W2064037332 cites W1594763965 @default.
• W2064037332 cites W1964498638 @default.
• W2064037332 cites W1981316146 @default.
• W2064037332 cites W1982771591 @default.
• W2064037332 cites W1989136905 @default.
• W2064037332 cites W1996567630 @default.
• W2064037332 cites W1997156142 @default.
• W2064037332 cites W2000724531 @default.
• W2064037332 cites W2001132729 @default.
• W2064037332 cites W2011579057 @default.
• W2064037332 cites W2034104654 @default.
• W2064037332 cites W2037343561 @default.
• W2064037332 cites W2042629233 @default.
• W2064037332 cites W2044290256 @default.
• W2064037332 cites W2047782940 @default.
• W2064037332 cites W2050976516 @default.
• W2064037332 cites W2057361916 @default.
• W2064037332 cites W2080665351 @default.
• W2064037332 cites W2092168876 @default.
• W2064037332 cites W2093979198 @default.
• W2064037332 cites W2129188204 @default.
• W2064037332 cites W2174778538 @default.
• W2064037332 cites W2182301936 @default.
• W2064037332 cites W2402587517 @default.
• W2064037332 cites W2406517552 @default.
• W2064037332 cites W2408857149 @default.
• W2064037332 cites W2409843294 @default.
• W2064037332 cites W2410448125 @default.
• W2064037332 cites W2411258767 @default.
• W2064037332 cites W2421395535 @default.
• W2064037332 cites W2421683436 @default.
• W2064037332 cites W2432372418 @default.
• W2064037332 cites W2435473651 @default.
• W2064037332 cites W2441057077 @default.
• W2064037332 cites W2607330284 @default.
• W2064037332 cites W269861981 @default.
• W2064037332 doi "https://doi.org/10.1016/0305-4179(93)90115-o" @default.
• W2064037332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8357476" @default.
• W2064037332 hasPublicationYear "1993" @default.
• W2064037332 type Work @default.
• W2064037332 sameAs 2064037332 @default.
• W2064037332 citedByCount "6" @default.
• W2064037332 countsByYear W20640373322021 @default.
• W2064037332 crossrefType "journal-article" @default.
• W2064037332 hasAuthorship W2064037332A5001509020 @default.
• W2064037332 hasAuthorship W2064037332A5030009904 @default.
• W2064037332 hasAuthorship W2064037332A5049475413 @default.
• W2064037332 hasAuthorship W2064037332A5052407008 @default.
• W2064037332 hasAuthorship W2064037332A5086685012 @default.
• W2064037332 hasConcept C105702510 @default.
• W2064037332 hasConcept C126322002 @default.
• W2064037332 hasConcept C141071460 @default.
• W2064037332 hasConcept C142724271 @default.
• W2064037332 hasConcept C159654299 @default.
• W2064037332 hasConcept C16685009 @default.
• W2064037332 hasConcept C189976730 @default.
• W2064037332 hasConcept C203014093 @default.
• W2064037332 hasConcept C204232928 @default.
• W2064037332 hasConcept C2776458125 @default.
• W2064037332 hasConcept C2777624698 @default.
• W2064037332 hasConcept C2780252810 @default.
• W2064037332 hasConcept C2780931953 @default.
• W2064037332 hasConcept C2911091166 @default.
• W2064037332 hasConcept C29730261 @default.
• W2064037332 hasConcept C542903549 @default.
• W2064037332 hasConcept C71924100 @default.
• W2064037332 hasConcept C98274493 @default.
• W2064037332 hasConceptScore W2064037332C105702510 @default.
• W2064037332 hasConceptScore W2064037332C126322002 @default.
• W2064037332 hasConceptScore W2064037332C141071460 @default.
• W2064037332 hasConceptScore W2064037332C142724271 @default.
• W2064037332 hasConceptScore W2064037332C159654299 @default.
• W2064037332 hasConceptScore W2064037332C16685009 @default.
• W2064037332 hasConceptScore W2064037332C189976730 @default.
• W2064037332 hasConceptScore W2064037332C203014093 @default.
• W2064037332 hasConceptScore W2064037332C204232928 @default.
• W2064037332 hasConceptScore W2064037332C2776458125 @default.
• W2064037332 hasConceptScore W2064037332C2777624698 @default.
• W2064037332 hasConceptScore W2064037332C2780252810 @default.
• W2064037332 hasConceptScore W2064037332C2780931953 @default.
• W2064037332 hasConceptScore W2064037332C2911091166 @default.
• W2064037332 hasConceptScore W2064037332C29730261 @default.
• W2064037332 hasConceptScore W2064037332C542903549 @default.
• W2064037332 hasConceptScore W2064037332C71924100 @default.
• W2064037332 hasConceptScore W2064037332C98274493 @default.
• W2064037332 hasIssue "4" @default.

• next