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- W206403734 abstract "8. ConclusionThe incidence of cancer increases with age in humans and in laboratory animals alike, but patterns of age-related distribution of tumors is different for different tissues and different tumors. Aging may increase or decrease the susceptibility of individual tissues to early carcinogens and usually facilitates promotion and progression of carcinogenesis. Aging may predispose to cancer by two mechanisms: tissue accumulation of cells in late stages of carcinogenesis and alterations in internal homeostasis, in particular, alterations in immune and endocrine system. Increased susceptibility to the effect of late-stage carcinogens is found both in aged animals and elderly humans, as predicted by the multistage model of carcinogenesis. Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. Insulin/insulin-like growth factor 1 (IGF-1) signaling molecules that have been linked to longevity include DAF-2 and InR and their homologues in mammals, and inactivation of the corresponding genes followed by the increase in life span in nematodes, fruit flies and mice. It is possible that the life-prolonging effects of caloric restriction are due to decreasing IGF-1 levels. A search of pharmacological modulators of insulin/IGF-1 signaling pathway mimetic effects of life span extending mutations or calorie restriction could be a perspective direction in regulation of longevity. Some old and new observations suggest that antidiabetic biguanides could be promising candidates for both the life span extension and the prevention of cancer." @default.
- W206403734 created "2016-06-24" @default.
- W206403734 creator A5062719301 @default.
- W206403734 date "2006-06-13" @default.
- W206403734 modified "2023-09-24" @default.
- W206403734 title "Biological Interactions of Aging and Carcinogenesis" @default.
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