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- W2064043294 abstract "Inhibitors with vicinal 4-fluorophenyl/4-pyridine rings on a five- or six-membered heterocyclic ring are known to inhibit the p38 mitogen-activated protein kinase (MAPK), which is a potential target for rheumatoid arthritis and several different types of cancer. Several substituted azastilbene-based compounds with vicinal 4-fluorophenyl/4-pyridine rings were designed using computational docking, synthesized, and evaluated in a cell-free radiometric p38α assay. The biochemical evaluation shows that the best inhibition (down to 110 nM) is achieved for azastilbene-based compounds having an isopropylamine substituent in the 2-position of the pyridine ring. The inhibition of p38 signaling in human breast cancer cells was observed for two of the compounds." @default.
- W2064043294 created "2016-06-24" @default.
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- W2064043294 date "2013-01-01" @default.
- W2064043294 modified "2023-09-26" @default.
- W2064043294 title "Azastilbenes: a cut-off to p38 MAPK inhibitors" @default.
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- W2064043294 doi "https://doi.org/10.1039/c3ob27449g" @default.
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