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- W2064049488 abstract "We investigated the accumulation of CPT-11 and its metabolite (SN-38) in various organs and toxicities on multiple injections of CPT-11 under clinical regimens in SD rats. CPT-11 (16.7 mg/kg equivalent to 100 mg/m2) was administered intravenously by a single injection, or by multiple injections in 1 course (once a week for three consecutive weeks) or 3 courses (1 course repeated 3 times at intervals of 2 weeks). There was no tendency for CPT-11 and SN-38 to accumulate in any organs regardless of the number of injections. Treatment-related changes were not observed in the general condition, body weight, hematology, biochemistry, and organ weights. Histopathological changes induced by CPT-11 were not persistent and the rats made a rapid recovery after the administrations. From these results, it is suggested that there is no toxicity caused by accumulation of CPT-11 and its active metabolite, SN-38, in organs under clinical regimens in rats." @default.
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- W2064049488 date "2000-01-01" @default.
- W2064049488 modified "2023-09-24" @default.
- W2064049488 title "No toxicity caused by organ accumulation of CPT-11 on multiple injections under clinical regimens in rats." @default.
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- W2064049488 doi "https://doi.org/10.2131/jts.25.5_393" @default.
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