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- W2064061503 abstract "Abstract Multiple bilateral fibroadenomas are uncommon. This finding in four women who had received renal transplants prompted further inquiry. A prospective study was performed on 39 women under the age of 55 years who had received a renal transplant at least 1 year earlier. Clinical examination and breast ultrasonography were performed. Factors considered included immuno-suppressive therapy, concurrent medication and renal function. Blood was taken for estimation of oestradiol, prolactin, follicle-stimulating hormone (FSH) and sex hormone binding globulin levels. Fibroadenomas were found in 13 of 29 women who had received cyclosporin A: multiple in ten and bilateral in five. No abnormal breast findings were seen in 10 patients immunosuppressed with steroids and azathioprine alone (χ2 = 7.30, 1 d.f., P<0.01). Serum oestradiol concentration was raised in women with fibroadenomas compared with that in those with normal breasts (P<0.05) and the level of FSH was lower (P<0.01). Cyclosporin A may act on breast fibroblasts by humoral mechanisms and direct action." @default.
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- W2064061503 date "1996-12-01" @default.
- W2064061503 modified "2023-09-29" @default.
- W2064061503 title "Cyclosporin A and multiple fibroadenomas of the breast" @default.
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- W2064061503 doi "https://doi.org/10.1002/bjs.1800831229" @default.
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