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- W2064069319 abstract "We have identified an estrogen receptor of approximately 29 kDa apparent molecular weight in human sperm membranes by ligand and Western blot analysis, respectively, using peroxidase-conjugated E2 and an antibody directed against the ligand binding region of the genomic receptor (αH222). Such receptor is functional since 17βE2 induces a rapid and sustained increase of intracellular calcium concentrations ([Ca2+]i) which is completely eliminated by preincubation with αH222. 17βE2 effects on calcium are clearly mediated by a membrane receptor, as they are reproduced by the membrane-impermeable conjugate of the hormone BSA-E2. Dose-response curve for this effect is biphasic with EC50s in the nanomolar and micromolar range. In addition to calcium increase, 17βE2 stimulates tyrosine phosphorylation of several sperm proteins including the 29-kDa protein band. Preincubation of human sperm with 17βE2 inhibits calcium and acrosome reaction increases in response to progesterone. We conclude that estrogens may play a role in the modulation of non-genomic action of progesterone (P) in human sperm during the process of fertilization." @default.
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- W2064069319 date "2000-03-01" @default.
- W2064069319 modified "2023-09-25" @default.
- W2064069319 title "A novel functional estrogen receptor on human sperm membrane interferes with progesterone effects" @default.
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- W2064069319 doi "https://doi.org/10.1016/s0303-7207(99)00220-8" @default.
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