FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064072892> ?p ?o ?g. }

• W2064072892 endingPage "L954" @default.
• W2064072892 startingPage "L945" @default.
• W2064072892 abstract "Studies of regulated mucin secretion from goblet cells in primary cultures of human bronchial epithelial (HBE) cells have suffered, generally, from poor signal-to-noise ratios, with reported secretory responses of <100% (less than onefold) relative to baseline. Using, instead, HBE cells grown as xenografts in the backs of nude mice, we found that UTP (100 micro M) stimulated strong mucin secretory responses from isolated, luminally perfused preparations. The peak response (10 min) for 11 control experiments (37 xenografts) was 3.3 +/- 0.05-fold relative to baseline, and the time-integrated response (60 min) was 23.4 +/- 0.5-fold. Because responses to ATP and UTP were approximately equal, an apical membrane P2Y(2)-receptor (R) is suggested. Additionally, ADP activated mucin release from HBE xenografts, whereas UDP and 2-methlythio-ADP did not, a pattern of response inconsistent with known purinoceptors. Hence, either a novel receptor to ADP is suggested or there is significant conversion of ADP to ATP by ecto-adenylate kinase activity. Adenosine and a nitric oxide donor were without effect. Consistent with P2Y(2)-R coupling to phospholipase C, HBE xenografts responded to ionomycin and PMA; however, they were recalcitrant to forskolin and chlorophenylthio-cAMP, and to 8-bromo-cGMP. Hence, human airway goblet cells, like those of other species, appear to be regulated primarily via phospholipase C pathways, activated particularly by apical membrane P2Y(2)-R agonists." @default.
• W2064072892 created "2016-06-24" @default.
• W2064072892 creator A5005672335 @default.
• W2064072892 creator A5015587381 @default.
• W2064072892 creator A5046597487 @default.
• W2064072892 creator A5078790179 @default.
• W2064072892 date "2003-06-01" @default.
• W2064072892 modified "2023-10-18" @default.
• W2064072892 title "Regulation of mucin secretion from human bronchial epithelial cells grown in murine hosted xenografts" @default.
• W2064072892 cites W106062352 @default.
• W2064072892 cites W1499941256 @default.
• W2064072892 cites W1568026330 @default.
• W2064072892 cites W1578786358 @default.
• W2064072892 cites W1589482850 @default.
• W2064072892 cites W1774349284 @default.
• W2064072892 cites W1796144808 @default.
• W2064072892 cites W1965081579 @default.
• W2064072892 cites W1966739501 @default.
• W2064072892 cites W1968531696 @default.
• W2064072892 cites W1980927246 @default.
• W2064072892 cites W1981453378 @default.
• W2064072892 cites W1998663576 @default.
• W2064072892 cites W2005285859 @default.
• W2064072892 cites W2022634662 @default.
• W2064072892 cites W2029100084 @default.
• W2064072892 cites W2032069841 @default.
• W2064072892 cites W2037385767 @default.
• W2064072892 cites W2038535094 @default.
• W2064072892 cites W2051343064 @default.
• W2064072892 cites W2076205950 @default.
• W2064072892 cites W2077364716 @default.
• W2064072892 cites W2078772336 @default.
• W2064072892 cites W2087714421 @default.
• W2064072892 cites W2090855473 @default.
• W2064072892 cites W2096405956 @default.
• W2064072892 cites W2104881442 @default.
• W2064072892 cites W2109173245 @default.
• W2064072892 cites W2112998606 @default.
• W2064072892 cites W2132251075 @default.
• W2064072892 cites W2134212296 @default.
• W2064072892 cites W2138599948 @default.
• W2064072892 cites W2147052384 @default.
• W2064072892 cites W2149658463 @default.
• W2064072892 cites W2156011409 @default.
• W2064072892 cites W2156553708 @default.
• W2064072892 cites W2160063518 @default.
• W2064072892 cites W2169344912 @default.
• W2064072892 cites W2180780341 @default.
• W2064072892 cites W2248072689 @default.
• W2064072892 cites W2271267173 @default.
• W2064072892 cites W2291558770 @default.
• W2064072892 cites W2398007418 @default.
• W2064072892 cites W2403645706 @default.
• W2064072892 cites W4230115907 @default.
• W2064072892 cites W54538561 @default.
• W2064072892 doi "https://doi.org/10.1152/ajplung.00410.2002" @default.
• W2064072892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12533443" @default.
• W2064072892 hasPublicationYear "2003" @default.
• W2064072892 type Work @default.
• W2064072892 sameAs 2064072892 @default.
• W2064072892 citedByCount "35" @default.
• W2064072892 countsByYear W20640728922012 @default.
• W2064072892 countsByYear W20640728922013 @default.
• W2064072892 countsByYear W20640728922014 @default.
• W2064072892 countsByYear W20640728922015 @default.
• W2064072892 countsByYear W20640728922017 @default.
• W2064072892 countsByYear W20640728922019 @default.
• W2064072892 countsByYear W20640728922020 @default.
• W2064072892 crossrefType "journal-article" @default.
• W2064072892 hasAuthorship W2064072892A5005672335 @default.
• W2064072892 hasAuthorship W2064072892A5015587381 @default.
• W2064072892 hasAuthorship W2064072892A5046597487 @default.
• W2064072892 hasAuthorship W2064072892A5078790179 @default.
• W2064072892 hasConcept C126322002 @default.
• W2064072892 hasConcept C134018914 @default.
• W2064072892 hasConcept C153911025 @default.
• W2064072892 hasConcept C160225129 @default.
• W2064072892 hasConcept C170493617 @default.
• W2064072892 hasConcept C179264091 @default.
• W2064072892 hasConcept C24998067 @default.
• W2064072892 hasConcept C2776989580 @default.
• W2064072892 hasConcept C2776991684 @default.
• W2064072892 hasConcept C2778597717 @default.
• W2064072892 hasConcept C2779276759 @default.
• W2064072892 hasConcept C2779508331 @default.
• W2064072892 hasConcept C3018436504 @default.
• W2064072892 hasConcept C49039625 @default.
• W2064072892 hasConcept C529295009 @default.
• W2064072892 hasConcept C54355233 @default.
• W2064072892 hasConcept C55493867 @default.
• W2064072892 hasConcept C57306754 @default.
• W2064072892 hasConcept C62478195 @default.
• W2064072892 hasConcept C71924100 @default.
• W2064072892 hasConcept C86803240 @default.
• W2064072892 hasConcept C95444343 @default.
• W2064072892 hasConceptScore W2064072892C126322002 @default.
• W2064072892 hasConceptScore W2064072892C134018914 @default.
• W2064072892 hasConceptScore W2064072892C153911025 @default.

• next