Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064089091> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2064089091 endingPage "956" @default.
- W2064089091 startingPage "951" @default.
- W2064089091 abstract "Limiting-dilution culture of murine Ly-2+ T cells with concanavalin A (Con A) and irradiated spleen filler cells produces, with high efficiency, cytolytic T lymphocyte (CTL) clones. With most mouse strains (including CBA and C57BL/6) the specificity of these CTL clones drops after day 6 of culture, so that by day 9 the majority of clones can lyse most murine target cells, whether syngeneic or allogeneic. The rate of specificity degradation and relative target cell preference varies with the mouse strain. Some strains (e.g. BALB/c) do not show this effect and CTL clones remain specific to day 9. Many low natural killer (NK) cell strains (e.g. C57BL/6J.bg) maintain CTL specificity in such cultures, but the correlation between CTL specificity and NK status is not absolute. Growth of BALB/c precursor cells on CBA filler cells leads to specificity degradation in the BALB/c CTL clones; however, the specificity of CBA-derived CTL clones is not maintained by growth on BALB/c fillers. The results suggest that specificity degradation is induced in the developing CTL-clone by factors in the culture environment, perhaps a soluble lymphokine (a differentiation factor) or by an infectious agent (an endogenous mouse virus). Although such CTL specificity loss may render many limiting dilution studies of the CTL specificity repertoire invalid, the problem may be bypassed by an appropriate choice of mouse strain." @default.
- W2064089091 created "2016-06-24" @default.
- W2064089091 creator A5063329786 @default.
- W2064089091 creator A5064135515 @default.
- W2064089091 date "1984-01-01" @default.
- W2064089091 modified "2023-09-23" @default.
- W2064089091 title "Degradation of specificity in cytolytic T lymphocyte clones: Mouse strain dependence and interstrain transfer of nonspecific cytolysis" @default.
- W2064089091 cites W1985130836 @default.
- W2064089091 cites W2005291107 @default.
- W2064089091 cites W2015376265 @default.
- W2064089091 cites W2035397258 @default.
- W2064089091 cites W2040636404 @default.
- W2064089091 cites W2053865293 @default.
- W2064089091 cites W2065704811 @default.
- W2064089091 cites W2107359414 @default.
- W2064089091 doi "https://doi.org/10.1002/eji.1830141016" @default.
- W2064089091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6333346" @default.
- W2064089091 hasPublicationYear "1984" @default.
- W2064089091 type Work @default.
- W2064089091 sameAs 2064089091 @default.
- W2064089091 citedByCount "14" @default.
- W2064089091 crossrefType "journal-article" @default.
- W2064089091 hasAuthorship W2064089091A5063329786 @default.
- W2064089091 hasAuthorship W2064089091A5064135515 @default.
- W2064089091 hasConcept C104317684 @default.
- W2064089091 hasConcept C147969180 @default.
- W2064089091 hasConcept C153911025 @default.
- W2064089091 hasConcept C154317977 @default.
- W2064089091 hasConcept C159047783 @default.
- W2064089091 hasConcept C167672396 @default.
- W2064089091 hasConcept C202751555 @default.
- W2064089091 hasConcept C203014093 @default.
- W2064089091 hasConcept C2779456560 @default.
- W2064089091 hasConcept C2992881475 @default.
- W2064089091 hasConcept C54355233 @default.
- W2064089091 hasConcept C73588182 @default.
- W2064089091 hasConcept C81089528 @default.
- W2064089091 hasConcept C86803240 @default.
- W2064089091 hasConcept C8891405 @default.
- W2064089091 hasConceptScore W2064089091C104317684 @default.
- W2064089091 hasConceptScore W2064089091C147969180 @default.
- W2064089091 hasConceptScore W2064089091C153911025 @default.
- W2064089091 hasConceptScore W2064089091C154317977 @default.
- W2064089091 hasConceptScore W2064089091C159047783 @default.
- W2064089091 hasConceptScore W2064089091C167672396 @default.
- W2064089091 hasConceptScore W2064089091C202751555 @default.
- W2064089091 hasConceptScore W2064089091C203014093 @default.
- W2064089091 hasConceptScore W2064089091C2779456560 @default.
- W2064089091 hasConceptScore W2064089091C2992881475 @default.
- W2064089091 hasConceptScore W2064089091C54355233 @default.
- W2064089091 hasConceptScore W2064089091C73588182 @default.
- W2064089091 hasConceptScore W2064089091C81089528 @default.
- W2064089091 hasConceptScore W2064089091C86803240 @default.
- W2064089091 hasConceptScore W2064089091C8891405 @default.
- W2064089091 hasIssue "10" @default.
- W2064089091 hasLocation W20640890911 @default.
- W2064089091 hasLocation W20640890912 @default.
- W2064089091 hasOpenAccess W2064089091 @default.
- W2064089091 hasPrimaryLocation W20640890911 @default.
- W2064089091 hasRelatedWork W1486874446 @default.
- W2064089091 hasRelatedWork W152541474 @default.
- W2064089091 hasRelatedWork W1590430292 @default.
- W2064089091 hasRelatedWork W1964955632 @default.
- W2064089091 hasRelatedWork W2023714767 @default.
- W2064089091 hasRelatedWork W2038272141 @default.
- W2064089091 hasRelatedWork W2069079289 @default.
- W2064089091 hasRelatedWork W2086526888 @default.
- W2064089091 hasRelatedWork W2091740192 @default.
- W2064089091 hasRelatedWork W2101929599 @default.
- W2064089091 hasVolume "14" @default.
- W2064089091 isParatext "false" @default.
- W2064089091 isRetracted "false" @default.
- W2064089091 magId "2064089091" @default.
- W2064089091 workType "article" @default.