Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064089385> ?p ?o ?g. }
- W2064089385 endingPage "228" @default.
- W2064089385 startingPage "223" @default.
- W2064089385 abstract "Previous studies in BALB/c mice revealed an adjuvant effect of di-(2-ethylhexyl) phthalate (DEHP) to simultaneously administered ovalbumin. DEHP is the most commonly used phthalate plasticizer. In vivo formed metabolites of DEHP are peroxisome-proliferator-activated receptor (PPAR) ligands, a group of chemicals that may have immunomodulatory properties. To study whether the PPARα receptor was involved in the adjuvant effect of DEHP, PPARα-deficient 129/Sv mice were exposed intraperitoneally to a mixture of OVA and DEHP, and the OVA-specific IgE, IgG1 and IgG2a responses were compared to the corresponding responses in the wild-type strain. The study showed that the adjuvant mechanism of DEHP is mediated through a PPARα-independent mechanism. Compared to mice only given OVA, DEHP induced highly increased levels of OVA-specific IgG1 and IgG2a, both in the wild-type and in the PPARα knock-out strains, indicating that DEHP is a mixed Th1/Th2 adjuvant." @default.
- W2064089385 created "2016-06-24" @default.
- W2064089385 creator A5036986227 @default.
- W2064089385 creator A5049550317 @default.
- W2064089385 date "2007-05-01" @default.
- W2064089385 modified "2023-10-08" @default.
- W2064089385 title "The adjuvant effect of di-(2-ethylhexyl) phthalate is mediated through a PPARα-independent mechanism" @default.
- W2064089385 cites W1615320989 @default.
- W2064089385 cites W1952312284 @default.
- W2064089385 cites W1965946273 @default.
- W2064089385 cites W1975899300 @default.
- W2064089385 cites W1981906652 @default.
- W2064089385 cites W1984188413 @default.
- W2064089385 cites W1994143412 @default.
- W2064089385 cites W1994277651 @default.
- W2064089385 cites W2012986012 @default.
- W2064089385 cites W2027998702 @default.
- W2064089385 cites W2029245561 @default.
- W2064089385 cites W2034901755 @default.
- W2064089385 cites W2044384549 @default.
- W2064089385 cites W2048760591 @default.
- W2064089385 cites W2062482845 @default.
- W2064089385 cites W2062975796 @default.
- W2064089385 cites W2065624367 @default.
- W2064089385 cites W2067065957 @default.
- W2064089385 cites W2078164026 @default.
- W2064089385 cites W2127323018 @default.
- W2064089385 cites W2127594582 @default.
- W2064089385 cites W2133659790 @default.
- W2064089385 cites W2133903680 @default.
- W2064089385 cites W2167908723 @default.
- W2064089385 cites W2168433233 @default.
- W2064089385 cites W4291113916 @default.
- W2064089385 doi "https://doi.org/10.1016/j.toxlet.2007.03.009" @default.
- W2064089385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17462839" @default.
- W2064089385 hasPublicationYear "2007" @default.
- W2064089385 type Work @default.
- W2064089385 sameAs 2064089385 @default.
- W2064089385 citedByCount "47" @default.
- W2064089385 countsByYear W20640893852012 @default.
- W2064089385 countsByYear W20640893852013 @default.
- W2064089385 countsByYear W20640893852014 @default.
- W2064089385 countsByYear W20640893852015 @default.
- W2064089385 countsByYear W20640893852016 @default.
- W2064089385 countsByYear W20640893852017 @default.
- W2064089385 countsByYear W20640893852018 @default.
- W2064089385 countsByYear W20640893852020 @default.
- W2064089385 countsByYear W20640893852021 @default.
- W2064089385 countsByYear W20640893852023 @default.
- W2064089385 crossrefType "journal-article" @default.
- W2064089385 hasAuthorship W2064089385A5036986227 @default.
- W2064089385 hasAuthorship W2064089385A5049550317 @default.
- W2064089385 hasConcept C104317684 @default.
- W2064089385 hasConcept C126322002 @default.
- W2064089385 hasConcept C134018914 @default.
- W2064089385 hasConcept C150903083 @default.
- W2064089385 hasConcept C170493617 @default.
- W2064089385 hasConcept C178790620 @default.
- W2064089385 hasConcept C185592680 @default.
- W2064089385 hasConcept C187345961 @default.
- W2064089385 hasConcept C188413054 @default.
- W2064089385 hasConcept C203014093 @default.
- W2064089385 hasConcept C207001950 @default.
- W2064089385 hasConcept C2776946954 @default.
- W2064089385 hasConcept C2777863537 @default.
- W2064089385 hasConcept C2781005124 @default.
- W2064089385 hasConcept C55493867 @default.
- W2064089385 hasConcept C63932345 @default.
- W2064089385 hasConcept C71924100 @default.
- W2064089385 hasConcept C86339819 @default.
- W2064089385 hasConcept C86803240 @default.
- W2064089385 hasConcept C8891405 @default.
- W2064089385 hasConcept C98274493 @default.
- W2064089385 hasConceptScore W2064089385C104317684 @default.
- W2064089385 hasConceptScore W2064089385C126322002 @default.
- W2064089385 hasConceptScore W2064089385C134018914 @default.
- W2064089385 hasConceptScore W2064089385C150903083 @default.
- W2064089385 hasConceptScore W2064089385C170493617 @default.
- W2064089385 hasConceptScore W2064089385C178790620 @default.
- W2064089385 hasConceptScore W2064089385C185592680 @default.
- W2064089385 hasConceptScore W2064089385C187345961 @default.
- W2064089385 hasConceptScore W2064089385C188413054 @default.
- W2064089385 hasConceptScore W2064089385C203014093 @default.
- W2064089385 hasConceptScore W2064089385C207001950 @default.
- W2064089385 hasConceptScore W2064089385C2776946954 @default.
- W2064089385 hasConceptScore W2064089385C2777863537 @default.
- W2064089385 hasConceptScore W2064089385C2781005124 @default.
- W2064089385 hasConceptScore W2064089385C55493867 @default.
- W2064089385 hasConceptScore W2064089385C63932345 @default.
- W2064089385 hasConceptScore W2064089385C71924100 @default.
- W2064089385 hasConceptScore W2064089385C86339819 @default.
- W2064089385 hasConceptScore W2064089385C86803240 @default.
- W2064089385 hasConceptScore W2064089385C8891405 @default.
- W2064089385 hasConceptScore W2064089385C98274493 @default.
- W2064089385 hasIssue "3" @default.
- W2064089385 hasLocation W20640893851 @default.
- W2064089385 hasLocation W20640893852 @default.
- W2064089385 hasOpenAccess W2064089385 @default.